Overview
4-Chloroacetophenone is an aromatic ketone derivative with a chloro group at the para position. It is a versatile intermediate in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, and fragrances. The compound is known for its distinct aromatic properties and reactivity, making it valuable in various industrial applications. First synthesized in the late 19th century, 4-Chloroacetophenone has since become a staple in chemical manufacturing. Its stability and reactivity under controlled conditions allow for its use in complex synthetic pathways, contributing to its widespread adoption in the chemical industry.
Physical and Chemical Properties
4-Chloroacetophenone appears as a white to pale yellow crystalline powder with a characteristic aromatic odor. It has a molecular weight of 154.59 g/mol and a density of 1.19 g/cm³. The compound melts at 20-23 °C and boils at 237-239 °C, making it stable under normal conditions. Solubility-wise, it dissolves readily in organic solvents like ethanol and ether but is only slightly soluble in water. Its chemical reactivity is influenced by the presence of the carbonyl group and the chloro substituent, enabling it to participate in reactions such as nucleophilic substitution and condensation.
Main Applications
In the pharmaceutical industry, 4-Chloroacetophenone serves as a key intermediate for synthesizing active pharmaceutical ingredients (APIs). It is used in the production of antihistamines, analgesics, and other therapeutic agents. The agrochemical sector utilizes it in the synthesis of pesticides and herbicides, leveraging its reactivity to create effective crop protection products. The fragrance industry values 4-Chloroacetophenone for its aromatic properties, incorporating it into perfumes and flavorings. Additionally, it is employed in organic synthesis to produce dyes, resins, and other specialty chemicals, highlighting its versatility across multiple industries.
Safety and Storage
4-Chloroacetophenone is classified as an irritant, posing risks to skin, eyes, and respiratory systems upon exposure. Proper handling requires the use of personal protective equipment (PPE), including gloves, goggles, and respirators. Spills should be contained and cleaned up immediately to prevent environmental contamination. Storage conditions are critical to maintaining the compound's stability. It should be kept in a cool, dry, well-ventilated area, away from heat sources and open flames. Containers must be tightly sealed to prevent moisture absorption and degradation. Compliance with local safety regulations is essential for safe handling and storage.
B2B Procurement Guide
When procuring 4-Chloroacetophenone, buyers should prioritize suppliers with verified certifications and a track record of reliability. Key factors to consider include purity levels (typically 98%-99%), packaging options (e.g., drums, bags), and compliance with international standards like REACH and ISO. Bulk purchases often come with cost advantages, but it's advisable to request samples for quality testing before committing to large orders. Lead times, shipping conditions, and supplier responsiveness are also critical considerations. Establishing long-term partnerships with reputable suppliers can ensure consistent quality and timely delivery.
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