4-Chloro-7-methoxyquinoline-6-carboxamide
Overview
4-Chloro-7-methoxyquinoline-6-carboxamide is a specialized quinoline derivative primarily utilized as a pharmaceutical intermediate. Its molecular structure features a chloro and methoxy substitution, contributing to its reactivity and utility in organic synthesis. This compound is often employed in the development of active pharmaceutical ingredients (APIs) and other fine chemicals. Its synthesis typically involves multi-step organic reactions, and its purity is critical for downstream applications.
Physical and Chemical Properties
The compound appears as an off-white to light yellow crystalline powder, with a molecular weight of 236.65 g/mol. It is soluble in common organic solvents such as DMSO and methanol but exhibits limited solubility in water. Key chemical properties include stability under standard conditions, though it may degrade when exposed to strong acids or bases. The presence of both chloro and methoxy groups makes it a versatile intermediate for further functionalization.
Main Applications
4-Chloro-7-methoxyquinoline-6-carboxamide is predominantly used in the pharmaceutical industry as a building block for APIs. It serves as a precursor in the synthesis of more complex molecules, particularly those targeting therapeutic applications. Additionally, it finds use in academic and industrial research for the development of novel compounds. Its role in organic synthesis is underscored by its ability to undergo various chemical transformations.
Safety and Storage
Proper handling of this compound requires the use of personal protective equipment (PPE), including gloves and safety goggles. It should be stored in a cool, dry environment, protected from light and moisture to maintain stability. In case of accidental exposure, immediate washing with water is recommended. Disposal should comply with local regulations for chemical waste to minimize environmental impact.
B2B Procurement Guide
When procuring 4-Chloro-7-methoxyquinoline-6-carboxamide, buyers should prioritize suppliers with verified certifications (e.g., ISO, GMP). Purity levels, typically ranging from 95% to 99%, should be confirmed via analytical certificates. Bulk purchases may qualify for discounts, but lead times should be considered. It’s advisable to request samples for quality testing before large-scale orders. Reliable suppliers often provide technical support and documentation for regulatory compliance.
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