Overview
4-Bromophenethylamine is an organic compound belonging to the class of phenethylamines, characterized by a bromine atom attached to the para position of the phenyl ring. It is widely used in pharmaceutical research and as an intermediate in the synthesis of more complex molecules. The compound is known for its role in the development of bioactive compounds and is often utilized in academic and industrial laboratories. Due to its structural features, 4-Bromophenethylamine serves as a versatile building block in organic chemistry. Its aromatic amine group makes it reactive towards various electrophiles, enabling the synthesis of a wide range of derivatives. Researchers value this compound for its ability to introduce bromine into molecular frameworks, which can be further modified through cross-coupling reactions.
Physical and Chemical Properties
4-Bromophenethylamine appears as a white to off-white crystalline powder with a melting point ranging between 65-68°C. It is soluble in common organic solvents such as ethanol, methanol, and diethyl ether but has limited solubility in water. The presence of the bromine atom increases the molecular weight and influences the compound's reactivity, making it useful in nucleophilic substitution reactions. The compound's stability under normal conditions allows for straightforward handling, though it should be protected from prolonged exposure to light and moisture to prevent degradation. Its molecular weight of 200.08 g/mol and the presence of both amine and bromine functional groups make it a valuable reagent in synthetic chemistry, particularly in the construction of complex organic molecules.
Main Applications
4-Bromophenethylamine is primarily employed as an intermediate in the pharmaceutical industry, where it is used to synthesize active pharmaceutical ingredients (APIs) and other bioactive compounds. Its bromine substituent allows for further functionalization, making it a key precursor in the development of drugs targeting neurological and psychiatric disorders. In addition to pharmaceuticals, this compound finds applications in chemical research, particularly in the study of structure-activity relationships (SAR). Researchers use it to explore the effects of bromine substitution on the biological activity of phenethylamine derivatives. Its versatility also extends to material science, where it serves as a building block for advanced organic materials.
Safety and Storage
Handling 4-Bromophenethylamine requires adherence to safety protocols to minimize risks associated with chemical exposure. The compound may cause skin and eye irritation, and inhalation of dust should be avoided. Personal protective equipment (PPE), including gloves, goggles, and lab coats, is recommended when working with this substance. Storage conditions are critical to maintaining the compound's integrity. It should be kept in a tightly sealed container, stored in a cool, dry place away from direct sunlight and moisture. Proper labeling and separation from incompatible substances, such as strong oxidizing agents, are essential to prevent accidental reactions and ensure workplace safety.
B2B Procurement Guide
When procuring 4-Bromophenethylamine, B2B buyers should prioritize suppliers who provide certificates of analysis (CoA) to verify purity and identity. The CAS number (1878-67-7) should be confirmed to ensure the correct compound is being purchased. Bulk orders may require negotiation on pricing and shipping terms, as the compound is often sold in small quantities for research purposes. Buyers should also consider the logistical aspects of procurement, such as packaging and transportation. Due to its chemical nature, the compound may require special handling or hazardous material shipping protocols. Establishing long-term relationships with reputable suppliers can ensure consistent quality and reliable delivery, which is crucial for industrial and research applications.
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