Overview
4-Arm PEG-Aldehyde is a star-shaped polyethylene glycol derivative functionalized with aldehyde groups at each terminal. This structure provides four reactive sites for covalent bonding with amines via Schiff base formation, making it invaluable for creating 3D molecular networks. Developed as an advanced biomaterial, it combines PEG's antifouling properties with tailored reactivity. As a crosslinker, it enables controlled hydrogel formation for tissue engineering and sustained drug release systems. Its water-soluble backbone and biocompatibility meet stringent requirements for medical applications. The molecular weight and arm length can be customized to adjust crosslinking density and mechanical properties of resulting materials.
Physical and Chemical Properties
The compound exhibits typical PEG characteristics including hydrophilicity, low toxicity, and resistance to protein adsorption. Each aldehyde group (-CHO) has high reactivity toward primary amines at physiological pH, forming stable imine bonds. The four-arm architecture provides enhanced functionality compared to linear PEG-aldehydes. Viscosity depends on molecular weight, with higher MW variants forming more viscous aqueous solutions. Thermal analysis shows decomposition around 200-250°C. FTIR spectroscopy confirms aldehyde peaks at ~1720 cm⁻¹. NMR reveals characteristic peaks for ethylene oxide units (3.6 ppm) and aldehyde protons (9-10 ppm).
Main Applications
In bioconjugation, 4-Arm PEG-Aldehyde links proteins, peptides, or nanoparticles through lysine residues, creating stable conjugates for diagnostic assays or targeted therapies. It's particularly useful for antibody modification while preserving antigen-binding sites. For tissue engineering, researchers employ it to fabricate injectable hydrogels that encapsulate cells. Crosslinking with collagen or chitosan produces scaffolds mimicking extracellular matrix properties. Drug delivery systems leverage its ability to form biodegradable networks for controlled payload release, with degradation rates tunable via PEG chain length.
Safety and Storage
Although generally low-toxicity, aldehyde groups may cause skin/eye irritation. Always use personal protective equipment (PPE) including nitrile gloves and safety goggles. Avoid generating dust during handling. Store sealed under argon or nitrogen at -20°C to prevent oxidation and moisture absorption. Desiccants should accompany shipments. Solutions should be prepared fresh or frozen at -80°C for short-term use. For long-term storage of derivatives, consider reducing imine bonds to more stable secondary amines using sodium cyanoborohydride.
B2B Procurement Guide
When sourcing 4-Arm PEG-Aldehyde, specify: 1) Exact molecular weight (e.g., 10 kDa), 2) Purity grade (standard ≥90%, biomedical ≥95%), 3) Endotoxin levels (<0.1 EU/mg for implants), 4) Functional group quantification (aldehyde content by titration/NMR). Bulk orders (100g+) typically receive 15-30% discounts. Verify supplier certifications (ISO 13485 for medical-grade material). Lead times range from 2 weeks (stock items) to 8 weeks (custom synthesis). Consider vendors providing characterization data (HPLC, MS, NMR) and batch-specific certificates of analysis.
Related Manufacturers
- 主营：甲氧基聚乙二醇、氨基聚乙二醇、羧基聚乙二醇、巯基聚乙二醇、羟基聚乙二醇、马来酰亚胺聚乙二醇、四臂聚乙二醇、荧光素聚乙二醇、叠氮聚乙二醇、硅烷聚乙二醇、炔基聚乙二醇、生物素聚乙二醇、丙烯酸酯聚乙二醇、活性脂聚乙二醇、Boc保护基团聚乙二醇、Fmoc保护基团聚乙二醇、生物素小分子PEG衍生物、甲氧基小分子PEG衍生物
- 主营：臂聚乙二醇丙醛、荧光染料、花青素染料
- 主营：生物素修饰蛋白、fitc标记蛋白、聚苯乙烯微球、四臂聚乙二醇醛基、pvc微球、嵌段共聚物、生物素标记、荧光标记、纳米颗粒、核苷糖、aie、复合微球、功能化载玻片、荧光染料、金属配合物、Mxene、介孔二氧化硅微球、磁性纳米颗粒、小分子PEG、聚合物、纳米金、聚合物微球、荧光微球、荧光探针、点击化学、小分子
- 主营：在水中、包含肽、含叠氮、3694-51-7、4727-50-8、3065-79-0、丙炔基、由氨基、菁染料、peg单元、具有炔、胺hcl盐、阿尔法、催化剂、peg试剂、结构式、氨基nh2、碘化物、具有两、带有炔、磺酸基、aminopeg8、甲基九、bcn基团、荧光素
- 主营：四臂聚乙二醇醛基、特殊peg
- 主营：碳材料、c60粉体、cotg昂星、四臂聚乙二醇醛基、双层昂星、分析仪bet、cvd石墨烯、单层昂星、3d多层独立、电位分析仪、富勒醇昂星、双层石墨烯、石墨烯昂星、油橄榄油荷、石墨烯粉体、荧光光谱仪、工业熔喷布、氧化石墨烯、氟化石墨烯、石墨烯薄膜、石墨烯浆料、水分测定仪、单层石墨烯、辅助激光解、水凝胶原液、漫反射测试昂
- 主营：多肽定制、荧光标记、磷脂、DMG-PEG、同位素、生物素标记
- 主营：乙醇胺、甲醚酰肼、单甲醚乙酸、mpeg-maca、聚乙二醇单甲醚、单甲醚氨基、马来酰亚胺、单甲醚马来、单甲醚叠氮、单甲醚丙炔、单甲醚卤代烃、单甲醚苯甲醛、甲醚环氧丙烷、甲基丙烯酸酯、甲醚二苯基环、甲醚异氰酸酯、单甲醚乙烯基
- 主营：催化剂、peg试剂、活性脂、cy5四氮、2406-34-0、cb-cyclam、dbco-acid、3694-51-7、2001-96-9、苯二胺、乙氧基、试剂cas、环辛烯、生物素、实验室、半乳糖、溴苯基、交联剂、环己炔、荧光素、ac4galnal、葡萄糖、环辛炔、直发cas、糖化学
- 主营：反应活、hydrazide、修饰剂、聚乙二醇、催化剂、糖蛋白、连接子、激动剂、聚合物、活性脂、胆固醇、钆特酸、催化性、dna标记、络合剂、荧光试剂、雨蛙素、乙二胺、ped结构、衍生物、化合物、链接剂、反应物、生物素
- 主营：聚乙二醇、单分散peg、马来酰亚胺
- 主营：红色荧光微球、核酸提取磁珠、红色羧基微球
- 主营：2d碳化钒、单层mbene、陶瓷材料、聚乙二醇、mab相材料、mbene前驱体、ti3c2tx柔性膜、免疫因子纳米载体服务
- 主营：PLGA、透明质酸、聚乙内酯、磷脂聚乙二醇、胆固醇聚乙二醇、功能化聚乙二醇、硬脂酸聚乙二醇、聚乳酸、葡聚糖、DOPE
- 主营：聚乙二醇、纳米颗粒、脂质体
- 主营：金纳米、三角片、麦芽糖、荧光素PEG醛基、羟丙基、ito薄膜、氮化钛、tio2纳米、碳粉tio2、修饰tio2、pd纳米笼、水溶伊红、纳米复合、磁性纳米、蛋白芯片、包硅金银、硅纳米线、包硅纳米、硅纳米管、螯合树脂、油溶性银、复合材料、薄膜定制、纳米粒子