4-Acetyl-2-methoxypyridine
Overview
4-Acetyl-2-methoxypyridine is an organic compound with a pyridine ring substituted by an acetyl group at the 4-position and a methoxy group at the 2-position. It is primarily used as an intermediate in pharmaceutical synthesis and as a flavoring agent due to its aromatic properties. The compound is synthesized through various organic reactions, including acetylation and methoxylation of pyridine derivatives. Its unique structure makes it valuable in producing complex molecules for medicinal chemistry and agrochemical applications.
Physical and Chemical Properties
4-Acetyl-2-methoxypyridine appears as a light yellow to white crystalline powder with a distinct aromatic odor. It has a molecular weight of 151.16 g/mol and a melting point range of 50-55°C. The compound is soluble in common organic solvents such as ethanol, methanol, and acetone but exhibits limited solubility in water. Its stability under normal storage conditions makes it suitable for long-term use in industrial applications.
Main Applications
The primary use of 4-acetyl-2-methoxypyridine is as an intermediate in pharmaceutical synthesis. It serves as a building block for active pharmaceutical ingredients (APIs) and other biologically active compounds. In addition to pharmaceuticals, it is employed in the flavor and fragrance industry due to its pleasant aroma. Its versatility also extends to agrochemicals, where it acts as a precursor for pesticides and herbicides.
Safety and Storage
Handling 4-acetyl-2-methoxypyridine requires standard laboratory safety practices. Avoid direct contact with skin, eyes, or inhalation of dust. Use gloves, goggles, and a lab coat when working with the compound. Storage should be in a tightly sealed container, placed in a cool, dry, and well-ventilated area away from incompatible substances. Keep away from heat sources and open flames to prevent decomposition or combustion.
B2B Procurement Guide
When procuring 4-acetyl-2-methoxypyridine, verify the CAS number (49851-31-2) and purity specifications to ensure product authenticity. Reputable suppliers should provide certificates of analysis (CoA) and material safety data sheets (MSDS). Consider factors such as batch consistency, lead times, and supplier reliability. Pricing varies depending on quantity and purity, with bulk purchases typically offering cost advantages. Always request samples for quality testing before large-scale procurement.
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