Overview
3alpha-Hydroxytanshinone is a diterpenoid quinone compound isolated from Salvia miltiorrhiza (Danshen), a herb widely used in traditional Chinese medicine. It is structurally related to tanshinones, a class of bioactive compounds known for their therapeutic effects. Research highlights its potential in treating cardiovascular diseases, inflammation, and oxidative stress-related conditions. This compound is primarily sourced through extraction and purification processes from Danshen roots. Its pharmacological properties make it a subject of interest in both academic and industrial research, particularly in drug development and nutraceuticals.
Physical and Chemical Properties
3alpha-Hydroxytanshinone appears as a reddish-brown crystalline powder with a molecular weight of 294.30 g/mol. It is soluble in dimethyl sulfoxide (DMSO) and ethanol but exhibits limited solubility in water. The compound is stable under recommended storage conditions but may degrade upon prolonged exposure to light or moisture. Its melting point ranges between 180-185°C, and its chemical structure includes a hydroxyl group at the 3alpha position, which contributes to its bioactivity. Analytical methods such as HPLC and NMR are commonly used to confirm its purity and structural integrity.
Main Applications
In pharmaceutical research, 3alpha-Hydroxytanshinone is studied for its cardioprotective effects, including anti-arrhythmic and anti-atherosclerotic properties. It also demonstrates anti-inflammatory and antioxidant activities, making it a candidate for treating chronic inflammatory diseases. Traditional Chinese medicine utilizes Danshen extracts containing this compound for improving blood circulation and alleviating chest pain. Additionally, it is explored in cosmetic formulations for its potential to reduce oxidative skin damage.
Safety and Storage
While 3alpha-Hydroxytanshinone is generally considered safe at therapeutic doses, proper handling is essential to avoid irritation. Use personal protective equipment (PPE) such as gloves and masks when handling the powder. Storage should be in airtight containers, away from light and humidity, at temperatures below 25°C. Long-term stability studies suggest minimal degradation under optimal conditions, but periodic purity checks are advisable for research-grade material. Dispose of waste according to local regulations for organic compounds.
B2B Procurement Guide
When procuring 3alpha-Hydroxytanshinone, prioritize suppliers with certifications (e.g., ISO, GMP) and transparent quality control processes. Request a Certificate of Analysis (COA) detailing purity (≥98% by HPLC), residual solvents, and heavy metal content. Bulk buyers should negotiate pricing for quantities above 100 grams. Logistics considerations include cold-chain shipping for large orders to prevent degradation. For research institutions, small-scale vendors offering milligram quantities with fast turnaround times may be preferable.
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