Overview
3,5-Dihydroxybenzaldehyde is an aromatic aldehyde with two hydroxyl groups at the 3 and 5 positions of the benzene ring. It is a versatile intermediate in organic synthesis, particularly in the production of pharmaceuticals and specialty chemicals. The compound's reactive functional groups make it valuable for constructing complex molecules. Its synthesis typically involves the formylation of resorcinol or oxidation of 3,5-dihydroxytoluene. The compound is commercially available in various purities, with higher grades (>98%) preferred for pharmaceutical applications.
Physical and Chemical Properties
3,5-Dihydroxybenzaldehyde appears as an off-white to light yellow crystalline powder with a characteristic aromatic odor. It exhibits moderate solubility in polar organic solvents like ethanol and methanol but is only slightly soluble in water. The compound is stable under normal storage conditions but may degrade upon prolonged exposure to light or oxidizing agents. Its melting point ranges between 180-185°C, and it does not readily vaporize at room temperature. The presence of both aldehyde and hydroxyl groups allows for diverse chemical reactions, including condensation, oxidation, and nucleophilic addition, making it a valuable building block in synthetic chemistry.
Main Applications
In the pharmaceutical industry, 3,5-Dihydroxybenzaldehyde serves as a key intermediate for synthesizing active pharmaceutical ingredients (APIs), including anticoagulants and antifungal agents. Its reactive sites enable the construction of heterocyclic compounds and complex molecular frameworks. The agrochemical sector utilizes this compound in the production of herbicides and plant growth regulators. Additionally, it is employed in dye synthesis, where it contributes to the formation of chromophores. Research laboratories also use it as a reagent for organic transformations and as a standard in analytical chemistry.
Safety and Storage
3,5-Dihydroxybenzaldehyde should be handled with care to avoid skin contact, inhalation, or ingestion. Personal protective equipment (PPE), including gloves, goggles, and lab coats, is recommended. In case of exposure, rinse affected areas with plenty of water and seek medical attention if irritation persists. Store the compound in a tightly sealed container in a cool, dry place, away from direct sunlight and oxidizing agents. Ensure proper ventilation in storage areas to prevent the accumulation of dust or vapors. Dispose of waste material in accordance with local environmental regulations.
B2B Procurement Guide
When procuring 3,5-Dihydroxybenzaldehyde, verify the CAS number (13677-79-7) to ensure product authenticity. Request a Certificate of Analysis (COA) from suppliers to confirm purity, typically ranging from 95% to 99%. Bulk purchases may qualify for discounts, but ensure the supplier can meet your required quantity and delivery timeline. Reliable suppliers often provide technical support and customized packaging options. Consider suppliers with ISO certification or compliance with Good Manufacturing Practices (GMP) for pharmaceutical-grade material. Sampling before large orders is advisable to assess product quality.
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