Overview
3,5-Dihydroxyacetophenone is an organic compound belonging to the acetophenone family, characterized by hydroxyl groups at the 3 and 5 positions of the benzene ring. It serves as a versatile intermediate in chemical synthesis, particularly in pharmaceuticals and fragrances. The compound is synthesized through Friedel-Crafts acylation or other hydroxylation methods. Its structural features make it valuable for further functionalization, enabling the production of more complex molecules. In industrial settings, it is typically supplied as a crystalline powder with high purity (>98%) to meet the demands of fine chemical applications.
Physical and Chemical Properties
3,5-Dihydroxyacetophenone is a white to pale yellow crystalline solid with a melting point of approximately 130-135°C. It exhibits moderate solubility in polar organic solvents like ethanol and methanol but is only slightly soluble in water. The hydroxyl groups contribute to its reactivity, allowing for derivatization in synthetic processes. The compound is stable under normal storage conditions but may degrade upon prolonged exposure to light or moisture. Its molecular weight of 152.15 g/mol and aromatic ketone structure make it a lightweight yet effective building block for larger organic molecules.
Main Applications
This compound is primarily used as an intermediate in pharmaceutical synthesis, where it contributes to the production of active pharmaceutical ingredients (APIs) and drug precursors. Its hydroxyl groups facilitate the creation of complex molecular architectures. In the fragrance industry, 3,5-dihydroxyacetophenone serves as a precursor for aroma chemicals, adding floral or woody notes to perfumes. Additionally, it finds niche applications in organic synthesis for research and specialty chemicals, particularly in academia and R&D laboratories.
Safety and Storage
3,5-Dihydroxyacetophenone requires careful handling due to potential skin and eye irritation. Personal protective equipment (PPE), including gloves and goggles, is recommended. Adequate ventilation should be maintained in workspaces to avoid inhalation of dust. For storage, the compound should be kept in a tightly sealed container in a cool, dry place, away from direct sunlight and incompatible materials. Long-term stability is ensured by minimizing exposure to humidity and extreme temperatures. Spills should be contained and disposed of in accordance with local regulations.
B2B Procurement Guide
When procuring 3,5-dihydroxyacetophenone, prioritize suppliers that provide certificates of analysis (CoA) to verify purity (>98%) and consistency. Bulk buyers should negotiate pricing based on volume, with prices typically ranging from $50 to $200 per kilogram depending on purity and supplier. Evaluate supplier reliability through third-party audits or customer reviews. For pharmaceutical applications, ensure compliance with Good Manufacturing Practices (GMP). Request samples for quality testing before large-scale purchases, and confirm logistical details such as lead times and packaging options (e.g., 25 kg drums or custom quantities).
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