Overview
3,5-Dibromopyridine is a brominated derivative of pyridine, characterized by two bromine atoms at the 3 and 5 positions of the pyridine ring. It serves as a versatile intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. Its bromine substituents enhance its reactivity, making it valuable for cross-coupling reactions and other transformations. This compound is typically synthesized through the bromination of pyridine or its derivatives. Due to its role as a building block, it is often supplied in high purity grades to meet the stringent requirements of industrial applications.
Physical and Chemical Properties
3,5-Dibromopyridine appears as a white to off-white crystalline powder with a molecular weight of 236.89 g/mol. It has a melting point of approximately 90-94°C and is soluble in common organic solvents such as ethanol, acetone, and dichloromethane, but exhibits limited solubility in water. The presence of bromine atoms imparts significant reactivity, enabling participation in Suzuki, Stille, and other palladium-catalyzed coupling reactions. Its stability under standard conditions makes it suitable for storage and handling in laboratory and industrial settings, though protection from moisture and light is recommended.
Main Applications
3,5-Dibromopyridine is primarily used as an intermediate in the synthesis of pharmaceuticals, where it contributes to the construction of active pharmaceutical ingredients (APIs). Its reactivity allows for the introduction of pyridine motifs into complex molecules, which are common in drug design. In agrochemicals, it serves as a precursor for herbicides, fungicides, and insecticides. Additionally, it finds use in specialty chemicals, including ligands for catalysis and materials science applications. Its versatility underscores its importance in industrial chemistry.
Safety and Storage
3,5-Dibromopyridine is classified as an irritant, posing risks to skin and eyes upon contact. Proper personal protective equipment (PPE), including gloves and goggles, should be worn during handling. Work should be conducted in a well-ventilated area or under a fume hood to minimize inhalation exposure. Storage recommendations include keeping the compound in a cool, dry place, away from light and moisture. Containers should be tightly sealed to prevent degradation. In case of spills, absorb with inert material and dispose of according to local regulations.
B2B Procurement Guide
When procuring 3,5-Dibromopyridine, prioritize suppliers with certifications such as ISO or GMP to ensure quality and consistency. Key specifications to verify include purity (typically ≥98%), CAS number (625-92-3), and packaging options (e.g., 1 kg, 5 kg, or bulk quantities). Prices commonly range between $100-$300 per kilogram, with discounts available for larger orders. Lead times may vary, so confirm availability in advance. For international shipments, ensure compliance with regulations regarding hazardous chemicals.
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