Overview
3-TYP is a selective inhibitor of Tryptophan Hydroxylase 2 (TPH2), an enzyme critical for serotonin synthesis in the brain. It is widely used in neuroscience research to investigate serotonin-related pathways and disorders such as depression, anxiety, and neurodegenerative diseases. The compound's high specificity makes it a valuable tool for studying serotonin's role in behavior and mood regulation. Researchers favor 3-TYP for its ability to selectively target TPH2 without significantly affecting other enzymes in the tryptophan metabolic pathway. This specificity reduces off-target effects, allowing for clearer experimental results in both in vitro and in vivo studies.
Physical and Chemical Properties
3-TYP is a white to off-white powder with a molecular weight of 388.35 g/mol. It is soluble in dimethyl sulfoxide (DMSO) and slightly soluble in ethanol, but insoluble in water. This solubility profile makes it suitable for laboratory use, where it is typically dissolved in DMSO before being diluted in aqueous buffers for experiments. The compound should be stored at -20°C in a dry, dark environment to maintain stability. Prolonged exposure to light, heat, or moisture can degrade its efficacy, so proper storage is essential for preserving its inhibitory properties.
Main Applications
3-TYP is primarily used in neuroscience research to study serotonin synthesis and its role in various neurological and psychiatric disorders. Researchers employ it to investigate conditions like depression, anxiety, and schizophrenia, where serotonin dysregulation is a key factor. Its selectivity for TPH2 allows for precise modulation of serotonin levels in experimental models. Beyond basic research, 3-TYP is also utilized in drug discovery programs aiming to develop novel therapeutics targeting serotonin pathways. Its ability to inhibit TPH2 without interfering with other enzymes makes it a valuable reference compound for screening and validating new drug candidates.
Safety and Storage
3-TYP should be handled with care in a laboratory setting. Personal protective equipment (PPE), including gloves and safety goggles, is recommended to avoid skin contact or inhalation. The compound is not intended for human or veterinary use and should only be used by trained professionals in controlled environments. Proper storage is critical to maintain the compound's stability. It should be kept at -20°C in a tightly sealed container, protected from light and moisture. Avoid repeated freeze-thaw cycles, as this may degrade the compound over time.
B2B Procurement Guide
When procuring 3-TYP for research purposes, buyers should prioritize suppliers with a proven track record in providing high-purity biochemicals. Request a Certificate of Analysis (COA) to verify the compound's purity, which should typically be ≥98%. Additionally, inquire about stability data and storage recommendations to ensure optimal performance in experiments. Bulk purchases may offer cost savings, but buyers should confirm the supplier's ability to provide consistent quality across batches. Consider lead times and shipping conditions, as temperature-sensitive compounds like 3-TYP require specialized packaging to prevent degradation during transit.
Related Manufacturers
- 主营：123、实验试剂
- 主营：抑制剂、化合物库、药物筛选、天然产物
- 主营：三相5线、工业插头、航空插座、3防水转换器、工业插座、航空连接器、芯电源插座、防水防尘插座、防水防尘插头、防水明装插座、户外防水插座、防尘防水插头、三相四线插座、输入电源插座、工业防水插座、工业电源插座、插头单相三线、防潮防水插座、防水暗装插座、工业防水插头、尼龙塑料插座
- 主营：防爆插头插座、MC型应急电源插头座、威浦插头插座、630A发电车用插座、IEC309电连接器、大电流插头插座、突破机柜PDU、工业插头插座、航空插头插座、工业插座箱、防爆插座箱、工业电缆连接器、曼奈柯斯插头插座、威浦连接器、电源检修插座箱、突破插排、犀牛插头插座、防爆工业连接器、插销、工业接线插座、工业防水插头、单相三极防爆插头插座、三相四极防爆插头插座、三相五极防爆插头插座、多芯防爆插头插座
- 主营：过滤器、传感器、滤芯、电离棒、电源、齿轮泵、编码器、流量计、平衡器、模块、弹簧、涂胶头、控制杆、压线钳、测试阀、压力计、锁紧环、连轴器、消音器、隔膜泵、气动阀、过滤箱、拉线盒、高温计、开关
- 主营：binks、ransburg、demag、stromag、HBM、KOLLMORGEN、HSB、FSG、DEVILBISS、BAUMULLER、COHERENT、TECNA、BAUMER、BUDERUS、DELTA、MAGTROL
- 主营：欧洲工业品、solartron、ringspann、ott-jakob、karlklein、MP Filtri、holland、JAHNS液压马达、DEVILBISS、Demag、Prosoft、Magtrol、Vogel 减速机
- 主营：工件夹具、工业泵阀、电机减速机
- 主营：编码器、传感器、电位器、电感、电容、精密电阻、贴片保险丝、轻触开关
- 主营：点胶枪、照明灯、传感器、cherry217083、403131sdv-p07、sickgse2s-n131、流量计、继电器、控制器、换向阀、减压阀、超声波、适配器、电位器、转换器、液压缸、8400series、1078series、内置轴承、通信模块、电动气动、温度开关、接近开关、隔离信号、德国点胶阀
- 主营：集成电路、三极管、二极管、电源IC、逻辑IC、接口IC、电容电阻、CPU、GPU、开关、继电器
- 主营：集成电路、二三极管、控制器、STP3N80K5、驱动器、晶振、IC芯片、连接器、电源芯片、开关、触发器、电感、电阻、电容、钽电容、抑制器、放大器、继电器、接口芯片、晶体管、存储器、传感器、微控制器、逻辑器件
- 主营：[]
- 主营：安费诺、德驰、德尔福、164163、哈丁、矢崎、住友、广濑、英飞凌、欧姆龙、控制器、莫仕、博世、KET、ITT、TE、JAE、JST
- 主营：稳压器ti、二极管ti、内存闪存、stm32l475rgt6、mc32pf3000a2ep、mic37100-3.3ws-tr、闪存存储器、数字隔离器