Overview
3-(Trifluoromethoxy)phenol is an organic compound with the molecular formula C7H5F3O2. It is a derivative of phenol where a trifluoromethoxy group is attached to the meta position of the benzene ring. This compound is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals due to its unique chemical properties. Its structure combines the aromaticity of phenol with the electron-withdrawing effects of the trifluoromethoxy group, making it a versatile building block in organic chemistry. The compound is typically supplied as a colorless to pale yellow liquid and is handled with care due to its reactivity.
Physical and Chemical Properties
3-(Trifluoromethoxy)phenol is a liquid at room temperature with a density of approximately 1.35 g/cm³. It has a boiling point range of 180-182 °C, making it relatively stable under standard conditions. The compound is soluble in common organic solvents such as ethanol, ether, and acetone but has limited solubility in water. The trifluoromethoxy group imparts significant electron-withdrawing characteristics, influencing the compound's reactivity in electrophilic aromatic substitution reactions. This property is particularly valuable in the synthesis of complex organic molecules where precise control over reactivity is required.
Main Applications
The primary use of 3-(Trifluoromethoxy)phenol is as an intermediate in the pharmaceutical and agrochemical industries. It serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and pesticide formulations. Its ability to introduce a trifluoromethoxy group into molecules enhances their biological activity and metabolic stability. In addition to its industrial applications, this compound is also utilized in academic research for the development of novel organic compounds. Its versatility and reactivity make it a valuable tool for chemists working on drug discovery and material science.
Safety and Storage
3-(Trifluoromethoxy)phenol should be handled with caution due to its potential health hazards. Direct contact with skin or eyes can cause irritation, and inhalation of vapors should be avoided. Proper personal protective equipment (PPE), including gloves and safety goggles, is recommended when working with this compound. Storage conditions are critical to maintaining the compound's stability. It should be kept in a cool, dry place, away from light and moisture. Containers must be tightly sealed to prevent contamination and degradation. In case of spills, absorb with inert material and dispose of according to local regulations.
B2B Procurement Guide
When procuring 3-(Trifluoromethoxy)phenol, it is essential to verify the purity and CAS number (1533-27-9) to ensure you are receiving the correct compound. Reputable suppliers should provide a Material Safety Data Sheet (MSDS) detailing handling, storage, and safety information. Prices can vary significantly based on purity and quantity, with reference ranges typically between $50 and $100 per gram. Bulk purchases may offer cost savings. Always confirm packaging options, as proper sealing is crucial to prevent degradation during transit. Establish a reliable supply chain to ensure consistent quality and availability.
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