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3-(tert-Butylthio)-2-aminopyridine

Updated: 2026-07-19

Overview

3-tert-Butylthio-2-aminopyridine is a specialized chemical compound primarily used in pharmaceutical research and organic synthesis. Its molecular structure features both an amino group and a thioether group, which contribute to its reactivity and utility in various chemical reactions. The compound is known for its role as an intermediate in the synthesis of more complex molecules, particularly in medicinal chemistry. Due to its functional groups, it is often employed in the development of drugs and other bioactive compounds. While not as commonly encountered as some other intermediates, it is valued for its specific reactivity profile in synthetic chemistry applications.

Physical and Chemical Properties

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3-tert-Butylthio-2-aminopyridine typically appears as a white to pale yellow crystalline solid. It is soluble in common organic solvents such as ethanol, methanol, and dichloromethane, which makes it convenient for laboratory use. The molecular weight is 182.29 g/mol, and its structure includes a pyridine ring substituted with an amino group and a tert-butylthio group. The presence of these functional groups influences its chemical behavior, making it a versatile building block in synthetic chemistry. However, detailed physical properties like melting point, boiling point, and density are not widely documented, which may require experimental determination for specific applications.

Main Applications

The primary use of 3-tert-Butylthio-2-aminopyridine is as an intermediate in pharmaceutical synthesis. It serves as a building block for more complex molecules, particularly those with potential biological activity. Researchers value it for its ability to introduce both sulfur and nitrogen functionalities into target compounds. In addition to pharmaceuticals, it finds occasional use in agrochemical research and specialty chemical manufacturing. Its reactivity makes it suitable for constructing heterocyclic compounds, which are prevalent in many drug molecules. However, its applications are niche, often limited to specific synthetic pathways in advanced chemical research.

Safety and Storage

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As with many chemical intermediates, 3-tert-Butylthio-2-aminopyridine requires careful handling to ensure safety. It should be stored in a cool, dry place, protected from light and moisture to maintain stability. Proper labeling and containment are essential to prevent accidental exposure. Personal protective equipment (PPE) such as gloves, lab coats, and safety goggles should be worn when handling this compound. Avoid inhalation, ingestion, or skin contact, and work in a well-ventilated area or fume hood. In case of exposure, follow standard first aid procedures and consult safety data sheets (SDS) for specific guidance.

B2B Procurement Guide

When procuring 3-tert-Butylthio-2-aminopyridine, B2B buyers should prioritize supplier reliability and product quality. Request a Certificate of Analysis (COA) to verify purity and confirm the compound meets the required specifications. Bulk purchases may require negotiation on pricing, which can vary significantly depending on quantity and supplier. It is advisable to establish relationships with specialized chemical suppliers who can provide consistent quality and technical support. Due to its niche applications, availability may be limited, so lead times should be factored into procurement planning. Always ensure compliance with local regulations regarding the purchase and transport of chemical substances.

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