Overview
3-Phenylacrylonitrile is an organic nitrile compound featuring a phenyl group attached to an acrylonitrile structure. It is primarily utilized as a versatile intermediate in chemical synthesis, particularly in pharmaceuticals and agrochemicals. The compound is synthesized through the reaction of benzaldehyde with acetonitrile or via other nitrile-forming processes. Its reactive nitrile group makes it valuable for further chemical modifications, such as hydrolysis or reduction reactions.
Physical and Chemical Properties
3-Phenylacrylonitrile is a colorless to pale yellow liquid with a characteristic aromatic odor. It is thermally stable but may polymerize under prolonged exposure to heat or light. The compound’s nitrile group (-C≡N) is highly polar, contributing to its solubility in organic solvents like ethanol and acetone. However, it is insoluble in water due to its hydrophobic phenyl group. Its boiling point ranges between 250-260°C, and it exhibits moderate density (1.0-1.1 g/cm³).
Main Applications
In the pharmaceutical industry, 3-phenylacrylonitrile serves as a precursor for active pharmaceutical ingredients (APIs) and fine chemicals. It is also used in agrochemicals for synthesizing herbicides and insecticides. Additionally, the compound finds niche applications in specialty chemicals, such as fragrances and dyes, where its aromatic structure enhances scent or color properties. Its reactivity allows for further derivatization to produce complex molecules.
Safety and Storage
3-Phenylacrylonitrile is classified as harmful if inhaled, ingested, or absorbed through the skin. Proper personal protective equipment (PPE), including gloves and goggles, is essential during handling. Storage should be in tightly sealed containers, away from direct sunlight and oxidizing agents. Ventilated areas are recommended to prevent vapor accumulation. Spills should be contained using inert absorbents and disposed of as hazardous waste.
B2B Procurement Guide
When procuring 3-phenylacrylonitrile, buyers should prioritize suppliers with verified CAS numbers (1885-38-7) and certificates of analysis (CoA) confirming purity (>98%). Bulk purchases may qualify for discounts, but storage capacity must align with shelf-life considerations. Reliable suppliers often comply with ISO or GMP standards, ensuring consistent quality. Request samples for lab testing before large orders, and confirm logistics options for hazardous chemical transport.
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