Overview
3-O-Methylorobol is a naturally occurring flavonoid, structurally related to orobol, with a methoxy group at the 3-position. It is found in certain plants and has garnered interest for its bioactive potential. Researchers study its antioxidant, anti-inflammatory, and possible chemopreventive effects, though clinical applications remain under investigation. As a specialized chemical, it is primarily used in academic and industrial research settings. Its stability and solubility profile make it suitable for in vitro and in vivo studies, particularly in pharmacology and biochemistry.
Physical and Chemical Properties
3-O-Methylorobol is a yellow to pale brown crystalline powder with a molecular weight of 316.26 g/mol. It exhibits moderate solubility in organic solvents like methanol and DMSO but is only sparingly soluble in water. The compound is stable under standard laboratory conditions but degrades under prolonged exposure to light or moisture. Its melting point ranges between 220-225°C, typical for flavonoid derivatives. Spectroscopic methods (UV, NMR) are commonly employed for identification and purity assessment, with HPLC being the gold standard for quantification in research samples.
Main Applications
In pharmaceutical research, 3-O-Methylorobol is investigated for its potential to modulate oxidative stress and inflammation pathways. Early studies suggest it may inhibit enzymes like cyclooxygenase (COX) or interact with cellular signaling proteins, though further validation is required. The compound is also used as a reference standard in analytical chemistry to identify or quantify related flavonoids in plant extracts. Nutraceutical companies explore its inclusion in antioxidant formulations, albeit at experimental stages due to limited safety data.
Safety and Storage
While 3-O-Methylorobol is not classified as highly hazardous, standard laboratory precautions apply. Use gloves and safety goggles to prevent skin/eye contact, and work in a well-ventilated area to avoid inhalation of fine particles. For long-term storage, keep the compound in an airtight container with desiccant packs, ideally at 2-8°C. Avoid freezing or exposure to humidity, which may compromise stability. Label containers clearly with hazard information, even if only for reference purposes.
B2B Procurement Guide
When sourcing 3-O-Methylorobol, prioritize suppliers with ISO certification or GMP compliance, especially for pharmaceutical-grade material. Request certificates of analysis (CoA) detailing purity (≥95% by HPLC), residual solvents, and heavy metal content. Bulk purchases (100g+) may qualify for discounts, but verify scalability of production. Lead times can vary due to the compound’s niche status—confirm availability before ordering. For international shipments, ensure compliance with customs regulations for laboratory chemicals.
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