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3-O-Ethyl Ascorbic Acid

Updated: 2026-08-03

Overview

Ethyl Ascorbic Acid, commonly referred to as Vitamin C Ethyl Ether, is a stable and highly effective derivative of ascorbic acid (Vitamin C). It is widely recognized for its antioxidant properties and ability to inhibit melanin production, making it a popular ingredient in skincare and cosmetic formulations. Unlike pure Vitamin C, which is highly unstable and prone to oxidation, Ethyl Ascorbic Acid offers superior stability and skin penetration, ensuring prolonged efficacy. This compound is synthesized through the ethylation of ascorbic acid, which enhances its lipid solubility and stability in formulations. Its ability to remain active in various pH levels and temperatures makes it a versatile ingredient in both aqueous and oil-based products. Ethyl Ascorbic Acid is particularly valued in anti-aging and brightening products, where it helps reduce hyperpigmentation and promote collagen synthesis.

Physical and Chemical Properties

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Ethyl Ascorbic Acid appears as a white to off-white crystalline powder with a molecular weight of 204.18 g/mol. It is soluble in water and ethanol, which facilitates its incorporation into a wide range of cosmetic and pharmaceutical formulations. The compound exhibits a melting point of approximately 170-175°C, indicating its stability under typical processing conditions. One of the key advantages of Ethyl Ascorbic Acid is its resistance to oxidation, a common issue with pure Vitamin C. This stability is attributed to the ethyl group, which protects the ascorbic acid moiety from degradation. Additionally, its lipid solubility enhances skin absorption, allowing for deeper penetration and prolonged activity. These properties make it an ideal choice for formulations requiring long shelf life and consistent performance.

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Main Applications

Ethyl Ascorbic Acid is predominantly used in the cosmetics and skincare industry, where it serves as a potent antioxidant and skin-brightening agent. It is a key ingredient in serums, creams, and lotions designed to reduce dark spots, even out skin tone, and combat signs of aging. Its ability to inhibit tyrosinase activity makes it effective in preventing melanin overproduction, resulting in a brighter and more radiant complexion. Beyond skincare, Ethyl Ascorbic Acid is also utilized in pharmaceutical applications, particularly in formulations targeting oxidative stress-related conditions. Its antioxidant properties help neutralize free radicals, protecting cells from damage. In some cases, it is incorporated into dietary supplements, although its primary use remains in topical applications due to its superior skin benefits.

Safety and Storage

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Ethyl Ascorbic Acid is generally considered safe for topical use, with minimal risk of irritation when used at recommended concentrations (typically 0.5%-3%). However, it is advisable to conduct patch tests before widespread application, especially for individuals with sensitive skin. Inhalation or ingestion should be avoided, as it may cause respiratory or gastrointestinal discomfort. Proper storage is essential to maintain the compound's stability and efficacy. It should be kept in a cool, dry place, away from direct sunlight and moisture. Sealed containers are recommended to prevent exposure to air, which could lead to oxidation. For bulk storage, nitrogen flushing or desiccants may be used to further enhance shelf life. Suppliers often provide certificates of analysis (COA) to verify purity and quality, which should be reviewed during procurement.

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B2B Procurement Guide

When sourcing Ethyl Ascorbic Acid for B2B purposes, it is crucial to prioritize quality and reliability. Buyers should verify the purity of the compound, typically requiring a minimum of 98% purity for cosmetic and pharmaceutical applications. Certifications such as COA, MSDS, and GMP compliance should be requested to ensure adherence to industry standards. Price ranges vary depending on quantity, purity, and supplier reputation, with common market prices ranging from $50 to $150 per kg. Bulk purchases may offer cost advantages, but it is essential to assess storage capabilities to prevent degradation. Establishing long-term relationships with reputable suppliers can ensure consistent quality and timely deliveries. Additionally, buyers should consider the supplier's ability to provide technical support and formulation advice, particularly for new or specialized applications.

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