3-Nitroisonicotinic Acid

Updated: 2026-09-16

Overview

3-Nitroisonicotinic Acid is a nitrated derivative of isonicotinic acid, primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing. Its molecular structure includes a nitro group attached to the pyridine ring, which enhances its reactivity in chemical reactions. This compound is valued for its role in producing more complex molecules, particularly in medicinal chemistry. The compound is typically supplied as a light yellow to yellow crystalline powder. It is stable under recommended storage conditions but may decompose at higher temperatures. Due to its specialized applications, it is commonly sourced by B2B buyers in the chemical and pharmaceutical industries.

Physical and Chemical Properties

3-Nitroisonicotinic Acid has a molecular weight of 168.11 g/mol and appears as a light yellow to yellow crystalline powder. It is soluble in organic solvents such as dimethyl sulfoxide (DMSO) but has limited solubility in water. The compound decomposes at temperatures around 200-220°C, making it unsuitable for high-temperature applications. The nitro group in its structure makes it a reactive intermediate, useful for further chemical modifications. Its stability under normal conditions allows for safe handling and storage, provided standard precautions are followed. The compound's solubility profile and reactivity are key factors in its industrial and laboratory applications.

Main Applications

3-Nitroisonicotinic Acid is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its reactive nitro group facilitates the construction of more complex molecules, making it valuable in medicinal chemistry. For example, it may serve as a precursor in the development of antibacterial or antiviral agents. In addition to pharmaceuticals, the compound finds use in research and development, particularly in organic synthesis laboratories. Its applications are niche but critical for producing specialized chemicals. The demand for this compound is driven by the pharmaceutical industry's need for high-purity intermediates.

Safety and Storage

Handling 3-Nitroisonicotinic Acid requires adherence to safety protocols to avoid health risks. The compound should not be inhaled, ingested, or allowed to contact skin or eyes. Personal protective equipment (PPE), including gloves and goggles, is essential when working with this chemical. Storage conditions should be cool, dry, and away from light and moisture to maintain stability. The compound should be kept in a tightly sealed container to prevent contamination or degradation. Proper disposal methods must be followed to minimize environmental impact.

B2B Procurement Guide

When procuring 3-Nitroisonicotinic Acid, buyers should prioritize suppliers with a proven track record in chemical manufacturing. Key considerations include verifying the compound's purity through a Certificate of Analysis (COA) and reviewing the Material Safety Data Sheet (MSDS) for safety information. Price ranges vary depending on quantity and supplier, so obtaining multiple quotes is advisable. Buyers should also assess logistics and storage capabilities to ensure the compound's integrity upon delivery. Establishing long-term relationships with reliable suppliers can streamline procurement processes.