Overview
3-Morpholinophenol is an organic compound belonging to the class of substituted phenols. It is widely used as a key intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. The compound features a morpholine ring attached to a phenol group, which enhances its reactivity and suitability for further chemical transformations. Due to its versatile applications, 3-Morpholinophenol is produced in industrial quantities by specialized chemical manufacturers. It is typically supplied as a white to off-white crystalline powder with high purity levels (≥98%). The compound is stable under normal storage conditions but should be handled with care to avoid contamination.
Physical and Chemical Properties
3-Morpholinophenol is characterized by its white to off-white crystalline appearance and a molecular weight of 179.22 g/mol. It has a melting point range of approximately 80-85°C, making it a solid at room temperature. The compound is soluble in common organic solvents such as ethanol, acetone, and dimethyl sulfoxide (DMSO), but exhibits limited solubility in water. The presence of both phenol and morpholine functional groups in the molecule contributes to its reactivity. It can undergo typical phenol reactions, such as etherification and esterification, while the morpholine ring can participate in nucleophilic substitution reactions. These properties make it a valuable building block for more complex chemical structures.
Main Applications
3-Morpholinophenol is primarily used as an intermediate in the pharmaceutical industry, where it serves as a precursor for the synthesis of various active pharmaceutical ingredients (APIs). It is particularly valuable in the production of drugs targeting the central nervous system (CNS) due to the morpholine moiety's ability to enhance bioavailability. In the agrochemical sector, the compound is employed in the synthesis of herbicides, fungicides, and insecticides. Additionally, it finds applications in the dye industry, where it is used to produce colorants with specific properties. Its versatility and reactivity make it a sought-after chemical in multiple industrial processes.
Safety and Storage
3-Morpholinophenol should be handled with appropriate safety measures to minimize exposure. Workers are advised to wear protective gloves, goggles, and lab coats to prevent skin and eye contact. Inhalation of dust or vapors should be avoided, and operations should be conducted in a well-ventilated area or under a fume hood. For storage, the compound should be kept in a tightly sealed container in a cool, dry place away from direct sunlight and moisture. It is stable under normal conditions but may degrade when exposed to strong acids, bases, or oxidizing agents. Proper labeling and segregation from incompatible materials are essential to ensure safe handling.
B2B Procurement Guide
When procuring 3-Morpholinophenol, B2B buyers should prioritize suppliers with a proven track record of quality and reliability. Key considerations include verifying the CAS number (10290-48-3) and requesting a Certificate of Analysis (COA) to confirm purity levels (typically ≥98%). Buyers should also inquire about packaging options, as the compound is commonly supplied in 25 kg drums or custom quantities. Pricing varies based on purity, quantity, and supplier location, with reference prices ranging approximately $50-$100 per kilogram. Establishing long-term contracts with reputable manufacturers can ensure consistent supply and favorable terms.
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