Overview
3'-Methoxypropiophenone is an organic compound belonging to the class of aromatic ketones. It features a methoxy group attached to the phenyl ring, making it a versatile intermediate in chemical synthesis. The compound is primarily used in pharmaceutical and fragrance industries due to its reactive carbonyl group and aromatic structure. Its synthesis typically involves Friedel-Crafts acylation or other organic reactions, yielding a product with high purity for industrial applications. As a B2B chemical, it is often supplied in bulk quantities to manufacturers requiring consistent quality and reliable supply chains.
Physical and Chemical Properties
3'-Methoxypropiophenone is a colorless to pale yellow liquid with a characteristic aromatic odor. It has a molecular weight of 164.20 g/mol and a density of approximately 1.05 g/cm³. The compound boils at around 250-252°C, though its melting point is not well-documented due to its liquid state at room temperature. It is soluble in common organic solvents such as ethanol, ether, and acetone but exhibits limited solubility in water. The methoxy group enhances its reactivity in electrophilic aromatic substitution reactions, making it valuable for further chemical modifications. Stability under normal conditions is good, but it should be protected from prolonged exposure to light and air to prevent degradation.
Main Applications
The primary use of 3'-Methoxypropiophenone is as an intermediate in the pharmaceutical industry, where it serves as a building block for active pharmaceutical ingredients (APIs). Its structure is particularly useful in synthesizing compounds with psychotropic or analgesic properties. In the fragrance industry, it contributes to the synthesis of aromatic compounds used in perfumes and flavorings. Additionally, it finds niche applications in organic research and specialty chemical production, where its ketone functionality is leveraged for complex molecular assemblies. The compound's versatility underscores its importance in fine chemical manufacturing.
Safety and Storage
3'-Methoxypropiophenone is classified as an irritant, posing risks to skin, eyes, and respiratory systems upon exposure. Proper personal protective equipment (PPE), including gloves and goggles, is essential during handling. A fume hood is recommended to minimize inhalation risks. Storage should be in tightly sealed containers, placed in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers. Shelf life is generally stable if stored correctly, but periodic checks for container integrity are advised. Spills should be contained and cleaned promptly using appropriate absorbent materials.
B2B Procurement Guide
When procuring 3'-Methoxypropiophenone, B2B buyers should prioritize suppliers with verified certifications (e.g., ISO, GMP) to ensure product quality and consistency. Key specifications to confirm include CAS number (586-37-8), purity levels (typically ≥98%), and absence of contaminants. Pricing varies based on order volume and purity, with bulk purchases often attracting discounts. Lead times and logistics options should be clarified, especially for international shipments. Reliable suppliers provide Material Safety Data Sheets (MSDS) and technical support, which are critical for regulatory compliance and safe handling in industrial settings.
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