3-Iodophenol[2]

Updated: 2026-09-20

Overview

3-Iodophenol is an aromatic organic compound belonging to the class of iodophenols. It is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. The compound features an iodine atom substituted at the meta position of the phenol ring, which enhances its reactivity in various chemical reactions. Due to its halogenated structure, 3-Iodophenol serves as a versatile building block in organic synthesis. It is commonly employed in cross-coupling reactions, such as Suzuki and Heck reactions, to create complex molecules. The compound is typically supplied as a crystalline solid and requires careful handling due to its potential irritant properties.

Physical and Chemical Properties

3-Iodophenol appears as a pale yellow to brown crystalline solid with a characteristic phenolic odor. It has a melting point of approximately 40-42°C and a boiling point around 220-222°C. The compound is soluble in common organic solvents like ethanol, ether, and acetone but exhibits limited solubility in water. The presence of the iodine atom in the meta position influences its chemical behavior, making it a valuable reagent in electrophilic substitution reactions. Its molecular weight is 220.01 g/mol, and it should be stored away from light and oxidizing agents to prevent degradation. The compound's stability under normal conditions makes it suitable for laboratory and industrial use.

Main Applications

3-Iodophenol is widely used in the pharmaceutical industry as an intermediate for synthesizing active pharmaceutical ingredients (APIs). Its role in agrochemical production includes the creation of herbicides and pesticides. Additionally, it serves as a precursor in the synthesis of dyes and other specialty chemicals. In research settings, 3-Iodophenol is utilized in cross-coupling reactions to form carbon-carbon bonds, a critical step in constructing complex organic molecules. Its reactivity and stability make it a preferred choice for chemists working on drug discovery and material science projects. The compound's applications are continually expanding as new synthetic methodologies are developed.

Safety and Storage

3-Iodophenol should be handled with care due to its irritant properties. Direct contact with skin or eyes can cause irritation, and inhalation of dust or vapors should be avoided. Proper personal protective equipment (PPE), such as gloves and safety goggles, is recommended when working with this compound. Storage conditions are critical to maintaining the compound's stability. It should be kept in a cool, dry place, away from light and oxidizing agents. Containers must be tightly sealed to prevent moisture absorption and contamination. Disposal should comply with local regulations for halogenated organic compounds to minimize environmental impact.

B2B Procurement Guide

When procuring 3-Iodophenol, B2B buyers should prioritize suppliers with a proven track record of reliability and quality. Key factors to consider include the compound's purity (typically ≥98%), CAS number verification, and packaging integrity. Bulk purchases may offer cost advantages, but storage capabilities should be assessed beforehand. Procurement professionals should also evaluate supplier certifications, such as ISO or GMP compliance, to ensure adherence to industry standards. Lead times and shipping conditions (e.g., temperature control) are additional considerations. For reference, prices commonly range between $50-$100 per gram, though bulk orders may negotiate lower rates. Always request safety data sheets (SDS) and certificates of analysis (CoA) for compliance and quality assurance.