Overview
3-Hydroxymelatonin is a primary metabolite of melatonin, formed through the hydroxylation of melatonin by cytochrome P450 enzymes. It is widely studied for its potent antioxidant properties and its role in protecting neural tissues from oxidative stress. This compound is particularly significant in research related to neurodegenerative diseases and aging. Its ability to scavenge free radicals makes it a valuable subject in studies aiming to understand and mitigate oxidative damage in biological systems.
Physical and Chemical Properties
3-Hydroxymelatonin is a white to off-white powder that is soluble in water, ethanol, and dimethyl sulfoxide (DMSO). Its molecular weight is 248.28 g/mol, and it shares structural similarities with melatonin, featuring an additional hydroxyl group at the 3-position. The compound's solubility in polar solvents makes it suitable for various experimental applications. However, its stability can be compromised by exposure to light and moisture, necessitating proper storage conditions to maintain its integrity.
Main Applications
3-Hydroxymelatonin is primarily used in scientific research, particularly in studies exploring its antioxidant and neuroprotective effects. It serves as a biomarker for melatonin metabolism and is investigated for potential therapeutic applications in neurodegenerative disorders like Alzheimer's and Parkinson's disease. In the pharmaceutical industry, it is explored as a component in formulations aimed at combating oxidative stress. Its role in circadian rhythm regulation and sleep-related research also makes it a compound of interest in neuroscience and pharmacology.
Safety and Storage
While 3-Hydroxymelatonin is not classified as highly hazardous, it should be handled with care to avoid inhalation or skin contact. Proper personal protective equipment (PPE), such as gloves and lab coats, is recommended when working with this compound. Storage should be in a cool, dry place, preferably in an airtight container protected from light and moisture. Stability can be ensured by monitoring the environment and avoiding extreme temperatures or humidity.
B2B Procurement Guide
When procuring 3-Hydroxymelatonin, B2B buyers should prioritize suppliers who provide detailed Certificates of Analysis (COA) to verify purity and composition. Reputable suppliers often offer technical data sheets and material safety data sheets (MSDS) for reference. Price ranges can vary significantly based on purity levels and supplier reliability. Bulk purchases may attract discounts, but it's essential to confirm batch consistency and storage recommendations from the supplier to ensure product quality upon delivery.
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