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3-Hydroxyglutaric acid

Updated: 2026-07-22

Overview

3-Hydroxyglutaric Acid (3-HGA) is an organic compound that plays a significant role in metabolic pathways, particularly in the breakdown of fatty acids and amino acids. It is a key intermediate in biochemical processes and is used extensively in research and industrial applications. The compound is synthesized through various biochemical routes and is often studied for its role in metabolic disorders. Its unique chemical properties make it valuable in pharmaceutical development and as a precursor in industrial chemical synthesis.

Physical and Chemical Properties

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3-Hydroxyglutaric Acid is a white crystalline powder that is hygroscopic and soluble in water. Its molecular formula is C5H8O5, with a molecular weight of 148.11 g/mol. The compound exhibits acidic properties and is reactive under certain conditions. The solubility of 3-HGA in organic solvents is limited, which influences its handling and storage requirements. Its stability is affected by environmental factors such as temperature and humidity, necessitating proper storage conditions to maintain its integrity.

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Main Applications

3-Hydroxyglutaric Acid is primarily used in biochemical research as a metabolite in studying metabolic disorders. It serves as a key intermediate in pharmaceutical synthesis, particularly in the development of drugs targeting metabolic diseases. In industrial settings, 3-HGA is utilized as a precursor in the production of specialty chemicals. Its role in metabolic pathways also makes it valuable in biotechnology and enzyme engineering applications.

Safety and Storage

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Proper handling of 3-Hydroxyglutaric Acid is essential to ensure safety. The compound should be stored in a cool, dry place, away from light and moisture to prevent degradation. Protective equipment such as gloves and goggles should be used to avoid skin and eye contact. In case of exposure, immediate rinsing with water is recommended. The compound should be kept away from incompatible materials, and spills should be cleaned up promptly using appropriate methods to avoid environmental contamination.

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B2B Procurement Guide

When procuring 3-Hydroxyglutaric Acid, buyers should prioritize suppliers with a proven track record of reliability and quality. It is essential to verify the purity and specifications of the compound to ensure it meets the required standards for the intended application. Price ranges can vary significantly based on purity and supplier, so obtaining multiple quotes is advisable. Buyers should also consider logistical factors such as storage and transportation conditions to maintain the compound's stability during transit.

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