Overview
3-Hydroxyflavone (3-HF) is a flavonoid derivative with a hydroxyl group at the 3-position of the flavone backbone. It is a yellow crystalline powder with notable fluorescent properties, making it valuable in biochemical and materials research. As a member of the flavonoid family, 3-HF shares structural similarities with natural plant pigments and exhibits antioxidant activity. Its synthetic versatility allows for modifications to enhance specific properties for targeted applications.
Physical and Chemical Properties
3-Hydroxyflavone has a molecular weight of 238.24 g/mol and typically appears as a pale yellow powder. It melts at approximately 170-174°C and is soluble in organic solvents like ethanol and DMSO but has limited solubility in water. The compound is known for its excited-state intramolecular proton transfer (ESIPT) capability, which results in dual fluorescence emission. This property is exploited in sensor development and photophysical studies. Its UV absorption maxima are around 340-360 nm, depending on the solvent.
Main Applications
In pharmaceuticals, 3-HF serves as an intermediate for synthesizing bioactive compounds with potential therapeutic effects. Its antioxidant properties are studied for applications in nutraceuticals and cosmetics. As a fluorescent probe, 3-HF is used to study membrane dynamics, protein interactions, and microenvironment polarity due to its sensitivity to changes in its surroundings. It is also employed in material science for developing organic light-emitting diodes (OLEDs) and sensors.
Safety and Storage
3-Hydroxyflavone should be handled with care to avoid inhalation or skin contact. Personal protective equipment (PPE) such as gloves and goggles is recommended during handling. For storage, keep the compound in a tightly sealed container in a cool, dry place away from light and moisture. Prolonged exposure to air or humidity may degrade its quality. Dispose of waste according to local regulations for organic compounds.
B2B Procurement Guide
When procuring 3-hydroxyflavone, prioritize suppliers with verified certifications (e.g., ISO, GMP) to ensure product quality. Key specifications to confirm include purity (typically 95-99%), CAS number (577-85-5), and batch testing reports. Bulk purchases may offer cost advantages, but storage capacity and shelf life should be considered. Sample testing is advisable for new suppliers. Lead times vary; ensure alignment with project timelines. For reference, prices range from $50-$200 per gram depending on purity and order volume.
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