Overview
3-Formylpyridine, also known as pyridine-3-carboxaldehyde, is an organic compound featuring a formyl group attached to the 3-position of a pyridine ring. It is a key intermediate in the synthesis of various pharmaceuticals, agrochemicals, and specialty chemicals. The compound is characterized by its reactive aldehyde group, which makes it a versatile building block in organic chemistry. Due to its reactivity, 3-formylpyridine is commonly used in the production of heterocyclic compounds and as a precursor in the synthesis of nicotine derivatives and other bioactive molecules. Its applications span across multiple industries, including pharmaceuticals, where it is used to develop drugs with therapeutic properties.
Physical and Chemical Properties
3-Formylpyridine is a colorless to pale yellow liquid with a density of 1.14 g/cm³ and a boiling point of 181-183 °C. It is soluble in water and most organic solvents, making it highly versatile for various chemical reactions. The compound's aldehyde group is highly reactive, enabling it to participate in condensation, oxidation, and nucleophilic addition reactions. The molecular weight of 3-formylpyridine is 107.11 g/mol, and its CAS number is 500-22-1. Its reactivity and solubility profile make it a valuable intermediate in organic synthesis, particularly in the formation of complex molecules for pharmaceutical and agrochemical applications.
Main Applications
3-Formylpyridine is widely used as an intermediate in the pharmaceutical industry, where it serves as a precursor for the synthesis of various drugs, including antihypertensive and antiviral agents. Its role in agrochemicals includes the production of pesticides and herbicides, where it contributes to the development of effective crop protection solutions. In addition to pharmaceuticals and agrochemicals, 3-formylpyridine is employed in the synthesis of specialty chemicals, such as dyes, fragrances, and flavoring agents. Its versatility and reactivity make it a valuable component in the production of high-value chemical products.
Safety and Storage
3-Formylpyridine is an irritant to skin and eyes, and proper protective equipment, such as gloves and goggles, should be worn when handling the compound. It should be stored in a cool, dry place away from light and oxidizing agents to maintain its stability and prevent degradation. In case of exposure, immediate washing with plenty of water is recommended. The compound should be handled in a well-ventilated area or under a fume hood to minimize inhalation risks. Proper disposal methods should be followed to ensure environmental safety.
B2B Procurement Guide
When procuring 3-formylpyridine, it is essential to verify the purity and quality of the product, as impurities can affect its performance in chemical reactions. Reputable suppliers should provide certificates of analysis (CoA) to confirm the product's specifications. Bulk purchases may offer cost advantages, but buyers should ensure that storage conditions are adequate to maintain the compound's stability. It is also advisable to establish long-term relationships with reliable suppliers to ensure consistent quality and availability.
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