3-Cyanobenzaldehyde
Overview
3-Cyanobenzaldehyde is an aromatic aldehyde with a nitrile functional group at the meta position. It is widely used as a key intermediate in organic synthesis and pharmaceutical manufacturing. The compound is valued for its reactivity, particularly in condensation and cyclization reactions. Industrial-grade material typically has a purity of 98% or higher, making it suitable for large-scale chemical processes.
Physical and Chemical Properties
3-Cyanobenzaldehyde appears as a pale yellow to white crystalline powder with a characteristic aromatic odor. It is stable under normal conditions but may decompose upon prolonged exposure to light or moisture. The aldehyde and nitrile groups make it reactive toward nucleophiles. It shows moderate solubility in common organic solvents but limited solubility in water. The melting point range of 80-82°C helps in identification and quality control.
Main Applications
In pharmaceuticals, 3-Cyanobenzaldehyde serves as a building block for active pharmaceutical ingredients (APIs), particularly in the synthesis of antihypertensive and CNS drugs. It is also employed in agrochemical production, dyes, and specialty chemicals. The compound's dual functionality allows for versatile use in heterocyclic chemistry and fine chemical synthesis.
Safety and Storage
Proper handling of 3-Cyanobenzaldehyde requires PPE including gloves, goggles, and respiratory protection if dust is present. It may cause skin and eye irritation upon contact. Store in tightly sealed containers away from oxidizers and moisture. Maintain storage temperatures below 30°C. Spills should be contained with inert absorbents and disposed of as hazardous waste.
B2B Procurement Guide
Industrial buyers should confirm technical specifications including purity (HPLC/GC analysis), residual solvent content, and crystal morphology. Bulk shipments typically come in 25kg fiber drums with polyethylene liners. Establish supplier qualifications by auditing GMP compliance, batch consistency, and documentation practices. Consider MOQs, lead times, and Incoterms when sourcing globally. Sample testing is recommended before large purchases.
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