Overview
3-Chloropropyne (propargyl chloride) is a versatile halogenated alkyne extensively used in organic synthesis. Its molecular structure combines a reactive triple bond with a chlorine atom, making it valuable for introducing propargyl groups into molecules. First synthesized in the early 20th century, it now serves as a key building block for pharmaceuticals like antifungal agents and CNS drugs. Industrial production typically involves the chlorination of propargyl alcohol or dehydrochlorination of 1,2,3-trichloropropane. As a B2B commodity, it is supplied by specialty chemical manufacturers in drums (25-200 kg) or ISO tanks. Global demand is steady, driven by pharmaceutical R&D and agrochemical formulations. Buyers should prioritize suppliers with strict QC protocols due to its sensitivity to polymerization and moisture.
Physical and Chemical Properties
3-Chloropropyne is a volatile liquid with a pungent odor, boiling at 57-59°C. Its density (0.97 g/cm³) is slightly lower than water, and it exhibits limited water solubility but high miscibility with ether, acetone, and hydrocarbons. The compound’s reactivity stems from both its terminal alkyne group (pKa ~25) and chlorine substituent, enabling nucleophilic substitutions and metal-catalyzed coupling reactions (e.g., Sonogashira). Key hazards include flammability (flash point -7°C) and toxicity (LC50 inhalation, rat: 4600 ppm/4h). It readily polymerizes when exposed to heat, acids, or metals like copper. Spectral characteristics include IR absorption at ~3300 cm−1 (C≡C-H stretch) and 1H NMR signals at δ 2.42 (CH2) and 3.02 ppm (C≡CH).
Main Applications
In pharmaceuticals, 3-chloropropyne is a precursor to propargylamine derivatives, which are structural motifs in MAO-B inhibitors (e.g., rasagiline for Parkinson’s disease). It also synthesizes antifungal agents like terbinafine. Agrochemical applications include the production of herbicides and plant growth regulators via nucleophilic displacement of its chlorine atom. The compound serves as a crosslinker in polymer chemistry, enhancing thermal stability in resins and rubbers. Specialty uses include corrosion inhibitors for oilfield chemicals and intermediates for fluorescent dyes. Emerging research explores its role in click chemistry (azide-alkyne cycloadditions) for bioconjugation and material science.
Safety and Storage
3-Chloropropyne requires stringent safety measures due to its flammability, toxicity, and lachrymatory effects. Storage mandates inert atmosphere (nitrogen/argon) in amber glass or polyethylene-lined steel containers, kept below 25°C. Incompatible materials include strong oxidizers, acids, and heavy metal salts that may catalyze violent decomposition. Spills should be neutralized with inert absorbents (vermiculite) and disposed as hazardous waste. Firefighting requires alcohol-resistant foam—water sprays may spread flames. First aid for exposure includes fresh air (inhalation), water flushing (eyes/skin for 15 mins), and immediate medical attention. Regulatory compliance includes OSHA PEL 1 ppm (skin) and DOT hazard class 3/6.1 labeling.
B2B Procurement Guide
Procuring 3-chloropropyne demands technical and regulatory diligence. Specify purity (≥95% by GC), moisture content (<0.1%), and inhibitor presence (e.g., 0.1% hydroquinone) to prevent polymerization. Request batch-specific COAs (Certificate of Analysis) and SDS aligned with GHS standards. Preferred packaging includes UN-certified drums with pressure relief valves. Leading suppliers are located in China, India, and Europe, with MOQs typically 50-100 kg. Negotiate incoterms (e.g., CIF for international shipments) and verify carriers’ hazardous material certifications. For quality assurance, conduct third-party testing for impurities like 1,2-dichloropropane. Long-term contracts with price adjustment clauses help manage cost volatility linked to chlorine and acetylene feedstock markets.
Related Manufacturers
- 主营：四氢噻吩、三甲基戊烷、乙硫醇、二甲基亚砜、氧化三甲胺、环丁砜、正己烯、单氰胺、氟硅酸、氯乙酸、氯乙酸钠、叔丁硫醇、对叔丁基邻苯二酚、氟硼酸、溶剂油、乙硫氨酯、苯扎溴铵、三聚氯氰、亚磷酸三苯酯、对氟苯胺、正己烷、邻苯基苯酚、苯酚、叔十二硫醇、二甲基二硫醚
- 主营：氯丙炔、油漆涂料、涂料溶剂
- 主营：肌氨酸钠、硫化锰、V50偶氮二异丁脒盐酸盐、PX-4MP、腰果酚缩水甘油醚、乙硫氮、二新癸酸二甲基锡、三硫代碳酸钠、芥酸PKO、四氧化三锰
- 主营：杀菌剂、椰子油、印染剂、氯丙炔厂家、阻燃剂、油酸锌、润湿剂、硫酸铯、催化剂、粘合剂、乳化剂、草酸锰、硫酸锂、石英砂、绝缘油、茶皂素、防腐剂、醋酸镁、锂电池、碘化锂、培养基、蒸馏水、硬脂酸、塑化剂、草酸钾、磷酸铁
- 主营：定香剂、氧化铅、浮选油、氯丙炔现货发送、氧化铋、氟化铝、氟化镁、洗涤剂、异丙醇、漂粉精、漂白粉、白僵菌、乙酸钡、氟化钙、水杨酸、松醇油、碳酸钡、醋酸钡、95福美钠、苯丙乳液、三乙二醇、鱼虾养殖、单乙醇胺、三乙醇胺、氯偏乳液、快干水泥
- 主营：蛋白栋、DOP、玻璃粉、氯丙炔货源、福美钠、黄糊精、硫酸钡、漂白粉、漂粉精、强氯精、优氯净、早强剂
- 主营：防酶剂、表面活性剂、次氯酸钙、氯丙炔价格、福美钠、蛋白胨、氟化氢钾、氟化钠、氟化钾、浮选油
- 主营：五氧化二钒、苄基胂酸、水杨酸、氯丙炔质量保障、水玻璃、氨基磺酸、多聚甲醛
- 主营：胰蛋白胨、骨蛋白胨、牛肉浸膏、氯丙炔湖北现货、福美钠、漂粉精、漂白精、次氯酸钙、单乙醇胺、三乙醇胺、三甘醇、防辐射钡粉、茶皂素、大苏打、小苏打、甘氨酸、九水硫化钠
- 主营：蛋白胨、牛骨蛋白胨、福美钠、氯丙炔本地供应商、强氯精、单乙醇胺、三乙醇胺、氯化铜、水玻璃、防辐射硫酸钡
- 主营：优氯净、甘氨酸、切削液、氯丙炔中间体、水杨酸、硫酸锰、平平加、滑石粉、牛磺酸、白僵菌、磷酸铁、铵明矾、蛋白胨、碳酸镁、磷酸铝、戊二醛、纤维素、硫化钠、硫化钡、黄蜂蜡、硫化钙、氯化锌、氯化锰、氧化锑、氧化锆、氧化锌
- 主营：福美钠、漂白粉、次氯酸钠、氯丙炔品质保证、强氯精、漂粉精、DOP、DBP、蛋白胨
- 主营：锚固剂、硫酸铝、硫酸铜、氯丙炔有机合成、切削液、氧化铜、溴化钠、大苏打、导热油、腐植酸、净洗剂、活性炭、水杨酸、硫酸锰、漂白粉、玻璃粉、茶皂素、丁酸钠、磷酸钙、甲酸钠、硬脂酸、消泡剂、酵母硒、磷酸铁、铵明矾、硫酸钡
- 主营：氯丙炔市场价格、福美钠
- 主营：白炭黑、白僵菌、eva乳液、t-31固化剂、棕榈蜡、pvc发泡剂、聚碳酸酯、聚乙烯蜡、苯甲酸铵