Overview
3'-Chloroacetophenone is an aromatic ketone derivative with a chlorine substituent at the meta position. It is a versatile intermediate in organic synthesis, particularly in pharmaceuticals and agrochemicals. The compound is characterized by its reactivity in carbonyl-based reactions, making it valuable for producing complex molecules. The demand for 3'-chloroacetophenone is driven by its role in synthesizing active pharmaceutical ingredients (APIs) and specialty chemicals. Its stability and solubility in organic solvents facilitate its use in industrial-scale reactions. Proper handling and storage are essential due to its irritant properties.
Physical and Chemical Properties
3'-Chloroacetophenone is a colorless to pale yellow liquid with a distinct aromatic odor. It has a melting point of 12-14°C and a boiling point of 245-247°C, making it stable under standard conditions. The compound's density is 1.19 g/cm³, and it is soluble in common organic solvents like ethanol and ether. Its chemical reactivity is dominated by the carbonyl group, which participates in nucleophilic addition and condensation reactions. The chloro substituent enhances its electrophilic character, enabling further functionalization. These properties make it a key building block in synthetic chemistry.
Main Applications
3'-Chloroacetophenone is primarily used as an intermediate in the pharmaceutical industry, where it contributes to the synthesis of antihistamines, antipsychotics, and other APIs. It is also employed in agrochemical production, particularly for pesticides and herbicides. In the fragrance industry, the compound serves as a precursor for musk-like scents. Its versatility extends to research laboratories, where it is used to develop new organic compounds. The demand for high-purity grades is increasing, especially in regulated industries.
Safety and Storage
3'-Chloroacetophenone is classified as an irritant and requires careful handling. Direct contact with skin or eyes can cause irritation, and inhalation of vapors should be avoided. Personal protective equipment (PPE), including gloves and goggles, is mandatory during use. Storage should be in tightly sealed containers, away from heat and light, in a well-ventilated area. Incompatible with strong oxidizing agents, it should be kept separate to prevent hazardous reactions. Spills should be contained and cleaned up immediately using appropriate absorbents.
B2B Procurement Guide
When procuring 3'-chloroacetophenone, buyers should prioritize suppliers with certifications like ISO or GMP, ensuring product quality and traceability. Key specifications to verify include purity (typically 98-99%), CAS number, and batch testing reports. Bulk purchases often come with cost advantages, but buyers should confirm storage and handling capabilities. Logistics considerations include temperature-controlled transport for large quantities. Establishing long-term supplier relationships can secure consistent quality and competitive pricing.
Related Manufacturers
- 主营：甜菊糖、氯乙酰、酞菁绿、二乙苯、4316-73-8、7783-40-6、1310-58-3、阻燃剂、二戊烯、单甲醚、硫酸锂、4861-19-2、大理石、1192-62-7、羊脂酸、磷酸氢、8002-74-2、7782-61-8、龙脑油、2842-44-6、聚甘油、二聚酸、戊二醇、聚醚f68、磺化油
- 主营：橡胶油、白芷油、7782-92-5、重质苯、1305-62-0、9005-32-7、1739-84-0、7786-30-3、pbtcaona4、艾叶油、二甲基、桉树醇、2905-60-4、5989-81-1、活性炭、1192-62-7、安息油、正辛烷、7775-27-1、8050-09-7、黄糊精、6920-22-5、三辛胺、1897-52-5、7727-21-1
- 主营：DMF、DMAC、二丙酮醇、间氯苯丙酮、四甲基胍、马来酸酐、丙二醇、乙二醇、甲酸、甲醇、十二醇、柠檬酸、己二醇、甘油、四氢呋喃、碳酸丙烯酯、吐温、无水氯化钙、乙酸乙酯、氢氧化钠、二乙醇胺、司盘、过硫酸钠、氧化钙、氯化钾
- 主营：二甲基亚砜、乙二醇、丙二醇、间氯苯丙酮、DMAC
- 主营：阻燃剂、乙酸镍、乙酸镝、氟苯基、硫酸锂、硫酸锶、溴氨酸、香茅醇、肌氨酸、锂电池、四氢萘、磷酸铬、碳酸镁、碳酸镍、防冻剂、磷酸铝、叔丁醇、浮选剂、稀释剂、羟乙基、去除剂、庚二酸、除磷剂、十八烯、蛋白酶
- 主营：吡咯酯、藜芦酮、麦芽酚、3-吲哚甲醛、β-氯代苯乙烷、铃兰醛、吴茱萸碱、聚谷氨酸、农药中间体、7-羟基香豆素、4-羟基香豆素、6-氰基-2-萘酚、5-甲氧基色胺、6-甲基香豆素
- 主营：间氯苯丙酮、乙酰丙酮氧
- 主营：石炭酸、特戊醛、乙氧基、碘苯基、5034-74-2、苯基溴、吡唑胺、碘乙烷、蚁酸钙、羟乙基、异恶唑、桶装液、碘酸钠、碘酸钾、碘酸钙、吡咯烷、溴己烷、创木酚、乙酸甲、氯化剂、2472-22-2、马来酸、二甲基、烯丙酯、润滑剂
- 主营：酰亚胺、异丙基、氨基丙基、苯甲醛、苯磺酸、cas-50-63-5、苯并三唑、氮杂苯并、磷酸二苯酯、试剂医药、化学醋酸、化学试剂、甲基硅基、盐酸羟胺、苄基丙酮、试剂化工、丙烯酰氯、甲基乙炔、二叔丁酯、化学碳酸钾、二酸二乙酯、酸二异丙酯、二咪唑羰基、中间体化工、医药中间体
- 主营：壬二酸、乙蒜素、氨乙基、143487-47-2、邻氯苯腈、苯基噻唑脲、基二苯甲烷、6-二氯苯腈、3，4-二氟苯腈、甲基苯甲酰胺、邻氰基苯甲醛、防腐剂、三唑硫酮、羟基硅油、二碳二酸、玫瑰精贝司、戊二烯二环、基三甲氧基、己二胺哌啶、氯代异丙烷、甘油基氨基、椰油酰胺丙基、甲基丙烯酸六、色谱分析试剂、双六氟磷酸盐
- 主营：间氯苯丙酮、双草酸酯、二茂铁甲醛
- 主营：二乙基、戊唑醇、甲醇钠、溴苯酞、苯丙醇、硝基苯、苯磺酸、溴丁烷、乙基溴、烟酰胺、叔丁醇、硫化钠、氢化钠、异戊醇、粉唑醇、肟菌酯、除氧剂、羟乙基、咪唑烷、甲基咪、牛磺胺、罗硝唑、乙酰溴、双甘膦、乙螨唑
- 主营：对二苯甲酸二肼
- 主营：阻聚剂、辛二醇、四甲基、3-二羟基萘、催化剂、十油酸酯、有机合成、硅化合物、光引发剂、十二酸己酯、月桂酸己酯、生物缓冲剂、表面活性剂、硫代卡巴肼、氨基甲酰甲基
- 主营：17746-77-9、三癸基铝、磺胺曲沙唑、625392-06-5、1423716-55-5、1547041-34-8、甲氧苯基、甲氧基苯甲酸、8-二羟基萘、三十二烷基铝、4-氯嘧啶盐酸盐