Overview
3-Bromoquinoline (CAS 5332-24-1) is a brominated derivative of quinoline, a heterocyclic aromatic compound. It serves as a versatile intermediate in organic synthesis, particularly in pharmaceuticals and agrochemicals. The bromine atom at the 3-position makes it a valuable building block for cross-coupling reactions and further functionalization. Quinoline derivatives like 3-bromoquinoline are widely studied due to their biological activity, including antimicrobial and anticancer properties. This compound is typically supplied as a crystalline powder and requires careful handling due to its reactivity.
Physical and Chemical Properties
3-Bromoquinoline is a pale yellow to light brown crystalline solid with a molecular weight of 208.06 g/mol. It has a melting point of approximately 50-55°C and is soluble in common organic solvents such as ethanol, acetone, and dichloromethane, but insoluble in water. The bromine substituent enhances its reactivity, making it suitable for palladium-catalyzed coupling reactions (e.g., Suzuki or Heck reactions). Its stability under normal storage conditions makes it a practical choice for laboratory and industrial use, though it should be protected from prolonged exposure to light and moisture.
Main Applications
3-Bromoquinoline is primarily used as an intermediate in the synthesis of pharmaceuticals, including potential drug candidates for treating infections or cancer. Its structure is a key scaffold in medicinal chemistry, enabling the development of quinoline-based therapeutics. In agrochemicals, it serves as a precursor for herbicides and fungicides. Additionally, it is employed in materials science for creating fluorescent dyes and coordination complexes. The compound's versatility in cross-coupling reactions makes it valuable for academic and industrial research.
Safety and Storage
3-Bromoquinoline is an irritant and should be handled with appropriate personal protective equipment (PPE), including gloves and safety goggles. Avoid inhalation of dust or vapors, and work in a well-ventilated area or fume hood. Store the compound in a tightly sealed container in a cool, dry place, away from direct sunlight and incompatible materials (e.g., strong oxidizers). Shelf life is typically several years when stored properly. Spills should be contained and cleaned up with inert absorbents, followed by proper disposal.
B2B Procurement Guide
When sourcing 3-Bromoquinoline, prioritize suppliers with certifications (e.g., ISO) and detailed product specifications. Key procurement criteria include purity (≥98%), CAS number verification, and batch-specific analytical reports (e.g., HPLC, NMR). Bulk purchases (kilograms or more) often qualify for discounts, but confirm lead times and shipping conditions (e.g., temperature control). For international transactions, ensure compliance with regional chemical regulations (e.g., REACH in the EU). Sample testing is recommended to confirm quality before large-scale orders.
Related Manufacturers
- 主营：全氟三丁胺、二苄叉山梨醇、六氟丙烯二聚体、溴喹啉、六氟环氧丙烷二聚体、异丙醇铝、纳米勃姆石、二异戊基硫醚、隐色结晶紫、邻菲罗啉
- 主营：阻燃剂、拉那白、牛儿酮、溴喹啉、海藻糖、热敏蓝、萘磺酸、氯菊酯、硫酸锌、催化剂、杨梅酯、檀香醚、聚醚胺、吸收剂、脂檀油、苍术素、羟钴胺、转移剂、溶剂绿、麝香酮、王浆酸、芬多精、纤维素、新戊酯、王冠醚、遮甜粉
- 主营：全氟三丁胺、全氟三乙胺、全氟三丙胺、123、全氟聚醚、全氟萘烷、全氟己酮、羟基磷灰石、生物活性玻璃、布洛芬、溴壬烷、磷酸铵、甲乙基、褪黑素、嘧啶钠、莪术油、显色剂、叔丁醇、茜素红、乙氧基、异戊醇、脯氨酸、茚三酮、氯唑沙
- 主营：增塑剂、草酸镍、阻燃剂、1-二十烯、栀子蓝、抗氧剂、偶联剂、异壬酸、间氟溴苄、异胞嘧啶、磷酸三钾、油墨油剂、洗涤助剂、苯磺酸钠、单体香料、环磺酮酸、分散染料、无机颜料、苹果酸镁、表面处理剂、丙二醇甲醚、化妆品原料、丁酸甘油酯、硅烷处理剂、表面活性剂
- 主营：5332、导电态聚苯胺
- 主营：聚苯胺、脯氨酸甲酯盐酸盐、苄基三甲基氯化铵
- 主营：全氟三丁胺、氢化镁、碳纳米管导电浆料、311-89-7、羟基磷灰石、提取物、树脂、硅烷、萃取剂
- 主营：溴喹啉生产企业、阿昔洛韦侧链、化工原料
- 主营：十八硫醇、碳酸铯、猪胆酸钠、脱氧胆酸钠、石胆酸、钛酸酯偶联剂、乙烯硫脲、单磷酸钠、玫瑰草油、乙酰化透明质酸钠、吗啉丙磺酸、亚甲基双丙烯酰胺、氧化锌、二甲基吡啶、聚醋酸乙烯酯、对碘苯甲酸甲酯
- 主营：溴喹啉、硅油树脂、中间体、香精香料
- 主营：氯化氢乙醇、二苯基硅二醇、甲基磺酸铋、溴喹啉、阻燃剂DDP、萃取剂、HTPB、防老剂
- 主营：三甲基戊二醇、三甲基戊二醇二苯甲酸、羟基乙酸、N-二羟乙基对甲苯胺、N-二异丙醇对甲苯胺、柠檬酸铝、间二三氟甲苯、双酚F
- 主营：防老剂、香精香料、乳化剂、溴喹啉、壳聚糖
- 主营：侧柏叶油、当归提取物、益智仁精油、溴喹啉、羟丙基硅油、侧柏叶精油、茴香提取液、墨旱莲提取物、接骨木提取液
- 主营：生物缓冲剂、苯甲酸系列、农药、合成中间体