Overview
3-Bromophenethylamine is a brominated derivative of phenethylamine, featuring a bromine atom at the meta position of the benzene ring. It serves as a versatile intermediate in organic synthesis, particularly in pharmaceutical research and fine chemical production. The compound is classified as an aromatic amine and shares structural similarities with other bioactive phenethylamines. Due to its reactive nature, 3-bromophenethylamine is primarily used in controlled laboratory settings. It is not commonly found in consumer products but plays a critical role in the development of specialized chemicals and drug candidates. Regulatory compliance is essential when handling this compound, as it may be subject to regional chemical control laws.
Physical and Chemical Properties
3-Bromophenethylamine appears as a white to off-white crystalline powder with a molecular weight of 200.08 g/mol. Its melting point ranges between 120-125°C, and it exhibits moderate solubility in polar organic solvents like ethanol and methanol. The bromine substituent enhances its reactivity in electrophilic aromatic substitution reactions. The compound's stability is influenced by storage conditions, with degradation risks under prolonged exposure to light or moisture. Analytical methods such as HPLC and NMR are typically employed to verify its purity. Industrial-grade samples may contain trace impurities, while research-grade material often exceeds 97% purity.
Main Applications
In pharmaceutical synthesis, 3-bromophenethylamine acts as a precursor for antidepressants, stimulants, and other CNS-targeting compounds. Its bromine atom facilitates further functionalization via cross-coupling reactions (e.g., Suzuki or Heck reactions), making it valuable for structure-activity relationship studies. The chemical is also utilized in academic research for developing novel heterocyclic compounds. Some specialty chemical manufacturers incorporate it into liquid crystal materials or agrochemical intermediates. Due to its niche applications, global production volumes are relatively low compared to bulk chemicals.
Safety and Storage
As a brominated aromatic amine, 3-bromophenethylamine requires careful handling to avoid inhalation or skin contact. Laboratories should implement engineering controls (fume hoods) and mandate PPE including nitrile gloves and safety goggles. Spill kits with inert absorbents must be readily available. Long-term storage recommendations include airtight containers under inert gas (e.g., nitrogen) at temperatures below 25°C. Incompatibilities include strong oxidizers and acids. Safety Data Sheets (SDS) must be consulted prior to use, and disposal should comply with local hazardous waste regulations.
B2B Procurement Guide
B2B buyers should prioritize suppliers with demonstrated expertise in brominated compounds. Key procurement considerations include batch-specific Certificates of Analysis (CoA), regulatory documentation (REACH, TSCA compliance), and scalable production capacity. Minimum order quantities (MOQs) typically start at 100g for research-grade material. Lead times vary from 2-8 weeks depending on customization requirements. Some suppliers offer contract synthesis for derivatives. Payment terms commonly involve 30-50% upfront for first-time buyers. International shipments may require hazardous material declarations and special packaging.
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