3-Bromo-5-(prop-1-yn-1-yl)pyridine
Overview
3-Bromo-5-(1-propynyl)pyridine is a brominated pyridine derivative with a propynyl substituent. It serves as a versatile intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. The compound's unique structure allows for further functionalization, making it valuable for constructing complex molecules. Due to its reactive bromine and alkyne groups, it is often used in cross-coupling reactions and other transformations. Its applications extend to the development of active pharmaceutical ingredients (APIs) and specialty chemicals.
Physical and Chemical Properties
3-Bromo-5-(1-propynyl)pyridine typically appears as a light yellow to brown solid. It is soluble in common organic solvents such as dichloromethane, ethanol, and acetone. The molecular weight is approximately 196.05 g/mol, and its stability under normal conditions makes it suitable for various synthetic applications. The presence of both bromine and an alkyne group in the molecule enhances its reactivity, allowing for selective modifications. However, precise data on melting and boiling points, as well as density, are often supplier-dependent and should be verified for specific batches.
Main Applications
This compound is primarily used as a building block in the synthesis of pharmaceuticals and agrochemicals. Its bromine atom facilitates palladium-catalyzed cross-coupling reactions, such as Suzuki or Sonogashira couplings, which are pivotal in drug discovery. Additionally, 3-Bromo-5-(1-propynyl)pyridine finds use in material science for creating functionalized polymers and ligands. Its versatility and reactivity make it a preferred choice for researchers and industrial chemists aiming to develop novel compounds with specific properties.
Safety and Storage
Proper handling of 3-Bromo-5-(1-propynyl)pyridine is essential to avoid health risks. It may cause skin and eye irritation upon contact, and inhalation of dust should be avoided. Always use personal protective equipment (PPE) such as gloves and goggles when working with this chemical. Storage recommendations include keeping the compound in a cool, dry place, away from direct sunlight and moisture. Containers should be tightly sealed to prevent degradation and contamination. For long-term storage, consider using inert atmospheres or desiccants to maintain stability.
B2B Procurement Guide
When procuring 3-Bromo-5-(1-propynyl)pyridine, buyers should prioritize suppliers with a proven track record in chemical manufacturing. Key factors to consider include purity levels, batch consistency, and compliance with regulatory standards such as REACH or GMP. Request certificates of analysis (CoA) to verify the compound's specifications. Pricing varies based on quantity and supplier, so obtaining quotes from multiple sources is advisable. For bulk purchases, negotiate terms for storage and delivery to ensure product integrity upon arrival.