Overview
3-Bromo-4-methylaniline is a brominated derivative of aniline, featuring a methyl group at the 4-position and a bromine atom at the 3-position of the benzene ring. It is a versatile intermediate in organic chemistry, particularly in the synthesis of pharmaceuticals, agrochemicals, and dyes. The compound is typically supplied as a crystalline powder and requires careful handling due to its toxicity.
Physical and Chemical Properties
3-Bromo-4-methylaniline is a pale yellow to brown crystalline solid with a molecular weight of 186.05 g/mol. It has a melting point of approximately 60-64°C and is soluble in common organic solvents such as ethanol and acetone but only slightly soluble in water. The bromine and methyl substituents influence its reactivity, making it useful for electrophilic substitution reactions and coupling reactions in synthetic chemistry. Its stability under normal conditions makes it suitable for storage, though it should be protected from light and moisture to prevent degradation. The compound's aromatic amine group is reactive, requiring precautions to avoid unwanted side reactions during synthesis.
Main Applications
This compound is primarily used as an intermediate in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs). It is also employed in agrochemical production, where it serves as a building block for herbicides and pesticides. Additionally, 3-bromo-4-methylaniline finds use in dye manufacturing, contributing to the production of vibrant and stable colorants. In research settings, it is valued for its role in organic synthesis, particularly in the development of novel compounds with potential biological activity. Its dual functional groups (bromo and amino) allow for diverse chemical modifications, making it a valuable tool for chemists.
Safety and Storage
3-Bromo-4-methylaniline is toxic if ingested or inhaled and can cause skin and eye irritation. Proper personal protective equipment (PPE), including gloves, goggles, and lab coats, must be worn when handling this compound. Work should be conducted in a fume hood to minimize inhalation risks. Storage requires a cool, dry environment away from light and oxidizing agents. Containers should be tightly sealed to prevent moisture absorption and contamination. Spills should be neutralized with appropriate absorbents and disposed of according to local regulations.
B2B Procurement Guide
When procuring 3-bromo-4-methylaniline, prioritize suppliers with verified certifications (e.g., ISO, GMP) to ensure product quality. Key specifications to check include purity (typically ≥98%), CAS number (583-74-6), and batch testing reports. Bulk purchases may offer cost advantages, but confirm storage and handling protocols with the supplier. Lead times and logistics should be clarified, especially for international shipments, to avoid delays. Some suppliers provide technical support or custom synthesis services, which can be beneficial for specialized applications.
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