Overview
2-Chloro-4-fluoro-5-nitrobenzoic acid (CAS: 282767-2) is a halogenated nitrobenzoic acid derivative with significant utility in fine chemical synthesis. Its molecular structure combines reactive functional groups—a carboxyl group, nitro group, and halogen substituents—making it a versatile intermediate for constructing complex molecules. Primarily employed in pharmaceutical and agrochemical research, this compound serves as a precursor for active ingredients and specialty chemicals. Its synthesis typically involves nitration and halogenation steps, with strict quality control to ensure consistency in industrial batches.
Physical and Chemical Properties
The compound appears as a light yellow to beige crystalline powder with a melting point range of 180-185°C. Its molecular weight is 219.55 g/mol, and it exhibits moderate solubility in polar organic solvents like dimethyl sulfoxide (DMSO) and methanol, though it has limited solubility in water. Key chemical properties include the reactivity of its nitro group (electrophilic substitution) and carboxyl group (esterification, amidation). The chlorine and fluorine atoms enhance its electrophilic character, facilitating further functionalization. Stability tests indicate it should be protected from prolonged exposure to light and humidity to prevent degradation.
Main Applications
In pharmaceuticals, this intermediate is used to synthesize drug candidates, particularly those targeting infectious diseases or cancer. Its nitro group can be reduced to an amine for further coupling reactions, while the carboxyl group allows for conjugation with other moieties. Agrochemical applications include its use in herbicide and pesticide development, where the halogenated aromatic core contributes to bioactivity. Additionally, it finds niche roles in materials science, such as modifying polymers or creating dyes. Demand is driven by R&D sectors requiring high-purity building blocks for scalable synthesis.
Safety and Storage
As a reactive chemical, 2-chloro-4-fluoro-5-nitrobenzoic acid requires careful handling. It may cause skin/eye irritation and respiratory discomfort if inhaled. PPE (nitrile gloves, safety goggles, lab coats) and fume hoods are mandatory during use. Storage recommendations include airtight containers in cool (15-25°C), dry conditions, away from oxidizing agents. Shelf life is typically 2-3 years when stored properly. Spills should be neutralized with inert absorbents and disposed of as hazardous waste, following local regulations.
B2B Procurement Guide
When procuring this chemical, prioritize suppliers with ISO certification and batch-specific Certificates of Analysis (CoA). Key specifications to verify are purity (≥98%), residual solvent levels, and heavy metal content. Bulk purchases (25kg drums) may reduce costs by 10-20%, but negotiate lead times as custom synthesis is common. Consider regional logistics—some vendors offer cold-chain shipping for stability. For international transactions, confirm compliance with REACH, TSCA, or other regional chemical inventories to avoid customs delays.
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