Overview
25-Hydroxyvitamin D, commonly referred to as calcidiol, is a prehormone produced in the liver as part of the vitamin D metabolic pathway. It is the primary circulating form of vitamin D and serves as a biomarker for assessing vitamin D status in clinical settings. The compound is derived from cholecalciferol (vitamin D3) through hydroxylation. Unlike the active form, calcitriol, 25-hydroxyvitamin D has a longer half-life, making it more suitable for diagnostic purposes. Its levels in the blood are indicative of overall vitamin D sufficiency or deficiency.
Physical and Chemical Properties
25-Hydroxyvitamin D is a sterol derivative with a molecular weight of 400.64 g/mol. It appears as a white to off-white crystalline powder and is soluble in organic solvents like ethanol and methanol but insoluble in water. The compound is sensitive to light and oxidation, requiring storage in a cool, dark environment. Its melting point ranges between 80-85°C, and it exhibits stability under recommended storage conditions. Proper handling is essential to maintain its integrity for diagnostic and research applications.
Main Applications
The primary use of 25-hydroxyvitamin D is in medical diagnostics, where it is measured to evaluate vitamin D status in patients. Low levels are associated with deficiencies that can lead to bone disorders like rickets or osteoporosis. Beyond diagnostics, it is used in dietary supplements to support bone health and immune function. Research applications include studies on its role in chronic diseases, autoimmune conditions, and metabolic disorders. Its stability and long half-life make it a preferred marker over other vitamin D metabolites.
Safety and Storage
25-Hydroxyvitamin D should be stored at -20°C in a tightly sealed container, protected from light and moisture. Prolonged exposure to air or improper storage can degrade the compound, affecting its efficacy. Safety precautions include wearing gloves and eye protection to avoid direct contact. Inhalation of dust should be avoided, and proper ventilation is recommended when handling the powder. Disposal should comply with local regulations for chemical waste.
B2B Procurement Guide
When procuring 25-hydroxyvitamin D, prioritize suppliers with certifications like ISO or GMP to ensure quality and purity. Request certificates of analysis (CoA) to verify the compound's identity and purity, typically ≥98% for research and diagnostic use. Bulk purchases may offer cost savings, but ensure proper storage facilities are available. Lead times can vary, so plan orders in advance. For reference, prices range from $50-$200 per milligram, depending on quantity and supplier reputation.
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