Overview
2,5-Dimethoxybenzaldehyde is an aromatic aldehyde with two methoxy groups attached to the benzene ring. It is widely used as a chemical intermediate in the synthesis of pharmaceuticals, fragrances, and other organic compounds. The compound is known for its distinct aromatic properties and reactivity, making it valuable in various industrial applications. Its synthesis typically involves the formylation of 1,4-dimethoxybenzene or oxidation of corresponding alcohols. The purity of 2,5-dimethoxybenzaldehyde is critical for its applications, especially in pharmaceutical manufacturing where high-grade intermediates are required.
Physical and Chemical Properties
2,5-Dimethoxybenzaldehyde appears as a white to pale yellow crystalline powder with a characteristic aromatic odor. It has a molecular weight of 166.17 g/mol and a density of 1.14 g/cm³. The compound melts at 72-75 °C and boils at approximately 285 °C. It is soluble in common organic solvents such as ethanol, acetone, and ether but has limited solubility in water. The presence of methoxy groups enhances its electron-donating properties, influencing its reactivity in electrophilic aromatic substitution reactions. These properties make it a versatile building block in organic synthesis.
Main Applications
2,5-Dimethoxybenzaldehyde is primarily used as an intermediate in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs). It is also employed in the production of fragrances and flavors due to its aromatic characteristics. In addition, it serves as a precursor in the synthesis of dyes, agrochemicals, and other specialty chemicals. Its reactivity allows for further functionalization, making it a valuable compound in research and industrial settings. The demand for high-purity 2,5-dimethoxybenzaldehyde is particularly strong in the pharmaceutical sector.
Safety and Storage
2,5-Dimethoxybenzaldehyde should be handled with care to avoid inhalation, ingestion, or skin contact. Proper personal protective equipment (PPE) such as gloves, goggles, and lab coats should be used when working with this chemical. Storage conditions should include a cool, dry place away from direct sunlight and moisture. The compound should be kept in tightly sealed containers to prevent degradation. In case of spills, absorb with inert material and dispose of according to local regulations. Always refer to the material safety data sheet (MSDS) for detailed safety instructions.
B2B Procurement Guide
When procuring 2,5-dimethoxybenzaldehyde, buyers should prioritize suppliers who provide a Certificate of Analysis (COA) to verify purity and quality. Bulk purchases may offer cost advantages, but storage capacity and shelf life should be considered. It is advisable to establish long-term relationships with reputable manufacturers to ensure consistent supply and quality. Buyers should also confirm packaging options, as proper packaging can prevent contamination and degradation during transit. Pricing varies based on purity and order volume, with typical ranges between $50-$100 per kilogram.
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