2,5-Dichloroacetophenone
Overview
2,5-Dichloroacetophenone is an important organic compound primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. Its molecular structure features a chloro-substituted benzene ring and an acetyl group, making it highly reactive in various chemical processes. This compound is typically supplied as a white to pale yellow crystalline powder. It is known for its stability under normal conditions but requires careful handling due to its irritant properties. Industrial applications leverage its reactivity to produce more complex molecules.
Physical and Chemical Properties
2,5-Dichloroacetophenone exhibits distinct physical and chemical properties that make it suitable for specialized applications. It has a molecular weight of 189.04 g/mol and a density of 1.36 g/cm³. The compound melts at 54-58 °C and boils at 265-267 °C. Its solubility profile shows good dissolution in organic solvents like ethanol and acetone, while it is only slightly soluble in water. These properties are critical for its use in organic synthesis, where solvent choice can significantly impact reaction efficiency.
Main Applications
The primary use of 2,5-dichloroacetophenone is as an intermediate in the pharmaceutical industry, where it contributes to the synthesis of active pharmaceutical ingredients (APIs). It is also employed in agrochemical production, particularly in the creation of pesticides and herbicides. Additionally, this compound finds applications in the dye industry, where it serves as a building block for complex dye molecules. Its versatility and reactivity make it a valuable component in various chemical manufacturing processes.
Safety and Storage
Handling 2,5-dichloroacetophenone requires strict adherence to safety protocols. The compound is an irritant to skin and eyes, necessitating the use of personal protective equipment (PPE) such as gloves and goggles. Always work in a well-ventilated area or under a fume hood. Storage conditions should be cool, dry, and away from light and moisture to maintain stability. Proper labeling and segregation from incompatible substances are essential to prevent accidental reactions or contamination.
B2B Procurement Guide
When procuring 2,5-dichloroacetophenone, it is crucial to verify the CAS number (897-92-7) to ensure product authenticity. Purity requirements should align with the intended application, as higher purity grades may be necessary for pharmaceutical use. Bulk purchases often provide cost advantages, but storage capacity and shelf-life considerations must be evaluated. Reliable suppliers should provide certificates of analysis (CoA) and material safety data sheets (MSDS) to confirm quality and safety specifications.
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