Overview
2,4,6-Trihydroxyacetophenone (THAP) is a phenolic derivative with a molecular formula of C8H8O4. It is widely recognized for its role as an intermediate in pharmaceutical synthesis and as an active ingredient in cosmetic formulations. The compound exhibits antioxidant and UV-absorbing properties, making it valuable in industries requiring stabilization against oxidative degradation. THAP is synthesized through the acetylation of phloroglucinol, a process that yields a high-purity product suitable for sensitive applications. Its compatibility with organic solvents and moderate solubility in water further enhances its utility in diverse chemical processes.
Physical and Chemical Properties
THAP appears as a pale yellow to white crystalline powder with a melting point range of 218-220°C. It is soluble in polar organic solvents like ethanol and methanol but has limited solubility in water. The compound's phenolic hydroxyl groups contribute to its acidity and reactivity in chelation and hydrogen bonding. Key chemical properties include its ability to scavenge free radicals and absorb UV light, which is leveraged in sunscreens and anti-aging products. Its stability under normal storage conditions makes it suitable for long-term use in formulated products, provided it is protected from moisture and light.
Main Applications
In the pharmaceutical industry, THAP serves as a building block for synthesizing flavonoids and other bioactive molecules. Its antioxidant properties are exploited in drug formulations aimed at reducing oxidative stress. The cosmetics industry utilizes THAP in skincare products, particularly those targeting UV protection and anti-aging. Its ability to inhibit melanin production also makes it a candidate for brightening formulations. Additionally, THAP is used in organic synthesis as a precursor for more complex phenolic compounds.
Safety and Storage
THAP requires careful handling due to its potential to cause skin and eye irritation. Personal protective equipment (PPE), including gloves and goggles, is recommended during manipulation. Inhalation of dust should be avoided by working in well-ventilated areas or under fume hoods. Storage conditions mandate a cool, dry environment away from direct sunlight. The compound should be kept in tightly sealed containers to prevent moisture absorption, which could lead to degradation. Shelf life typically exceeds two years when stored correctly.
B2B Procurement Guide
When procuring THAP, prioritize suppliers with ISO or GMP certifications to ensure quality and consistency. Key specifications to verify include purity (≥98%), CAS number (480-66-0), and absence of heavy metals. Batch-specific certificates of analysis (CoA) are essential for compliance in regulated industries. Pricing varies based on order volume and purity grades. Bulk purchases (100+ kg) often attract discounts. Consider regional suppliers to minimize logistics costs, but ensure they meet international safety and quality standards. Sample testing is advisable before large-scale orders.
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