Overview
2,4-Dichloropyridine is an organochlorine compound derived from pyridine, featuring chlorine substitutions at the 2- and 4-positions. It serves as a versatile building block in organic synthesis, particularly for pharmaceuticals and agrochemicals. The compound's reactivity stems from the electron-withdrawing effects of chlorine atoms, making it a valuable intermediate for nucleophilic substitution and metal-catalyzed cross-coupling reactions. Industrial production typically involves direct chlorination of pyridine under controlled conditions.
Physical and Chemical Properties
As a crystalline solid, 2,4-dichloropyridine exhibits moderate stability under standard conditions but may decompose under prolonged exposure to heat or UV light. Its solubility profile favors organic solvents, aligning with its use in reaction systems like THF or DMF. Key chemical behaviors include susceptibility to nucleophilic aromatic substitution (SNAr) at the C-2 position due to lower steric hindrance. The compound's molecular weight (147.99 g/mol) and density (~1.40 g/cm³) are critical for stoichiometric calculations in synthesis workflows.
Main Applications
In pharmaceuticals, 2,4-dichloropyridine is a precursor for antiviral and antitumor agents, where its chlorine atoms are displaced to form bioactive heterocycles. Agrochemical manufacturers use it to synthesize herbicides and fungicides with pyridine cores. The compound also facilitates ligand design in catalysis, particularly for palladium-catalyzed couplings like Suzuki-Miyaura reactions. Recent research explores its utility in materials science for constructing conjugated polymers with optoelectronic properties.
Safety and Storage
Classified as harmful if inhaled or ingested, 2,4-dichloropyridine requires handling in fume hoods with appropriate PPE (nitrile gloves, chemical goggles). Spills should be contained with inert absorbents and disposed as hazardous waste. Storage recommendations include amber glass containers under nitrogen atmosphere to prevent degradation. Incompatibilities include strong oxidizers and alkali metals. SDS documentation must be reviewed prior to large-scale use.
B2B Procurement Guide
Bulk procurement should prioritize suppliers with ISO 9001 certification and detailed COA (Certificate of Analysis) specifying purity (≥98%), residual solvents, and heavy metal content. Packaging options range from 1 kg bottles to 25 kg fiber drums. Buyers should confirm logistics compliance for hazardous chemical transport (UN proper shipping name: 'Chlorinated pyridines'). MOQs typically start at 100 kg, with price breaks at metric ton quantities. Sample testing for reaction suitability is advised before large orders.
Related Manufacturers
- 主营：聚乙烯亚胺、三甘醇二异辛酸酯3G8、三硫代碳酸钠40%、TS-1钛硅分子筛、5-甲基靛红、六氯环三磷腈、烷基苯磺酸酯、苯基次磷酸钠、甲巯咪唑、吡啶硫酮锌、焦磷酸哌嗪、热敏材料、油酸甲酯、曲酸
- 主营：杀虫剂、除草剂、10%啶虫脒、24、杀菌剂
- 主营：硫酰胺、抗氧剂、氟苯基、2-戊酮酸、l-脯氨酰胺、l-苯基乳酸、l-氨基丙醇、d-苯基乳酸、2-甲基丁酸、2-甲基丁酯、3-氨基丙醇、2-氰基嘧啶、中间体、溴咪唑并、焦谷氨醇、异丁酰胺、利伐沙班、对氰基苯酚、邻氟苯甲酸、邻溴苯乙酸、间溴苯甲酸、丁位癸内酯
- 主营：甘氨酸、溴化物、戊酸鈉、蒽甲酸、联吡啶、紫苏葶、锂电池、牛磺酸、褪黑素、磷酸铟、新癸酸、赖氨酸、溴化鏻、乙氧基、藏花醛、豆甾醇、羟乙基、维素酶、圣草酚、庚二酸、呋虫胺、丹参素、萘甲醛、槐豆胶、黄柏酮
- 主营：DTT、DMAA、三羟甲基氨基甲烷、6-kt、N-二乙基丙炔胺、5-二甲基海因、N-甲基吡咯烷酮、三羟甲基氨基甲烷盐酸盐、联枯、联苯二酚、DBU、对溴苯氧乙酸、赤霉素、敌草隆、丙炔氟草胺、啶嘧磺隆、甲嘧磺隆、噻吩磺隆、三氟啶磺隆、乙酰丙酮铝、异氰尿酸三缩水甘油酯、甲哌鎓、氯酯磺草胺
- 主营：乙醛酸、铁甲酸、二甲基、3-氯丙炔、3-氯水扬酸、2-羟基喹喔啉、2-苯并唑啉酮、3-环戊二羧酸、6-二氯异烟酸、2-氨基-5-氯苯酚、羟乙基、草酰胺、邻苯二甲、苯甲酰胺、溴氯海因、磷酸三甲酯、对羟基苯海因
- 主营：钼酸铋、钨管靶、铜镍管、1272-23-7、硅化钛、锆酸锂、钛靶材、甲醇钽、催化剂、钒酸铋、硼化铪、硅化钨、硼化锆、羧酸酯、钛锆管、保护管、复合板、核锆管、纯铌管、冷凝器、钛板网、涂钽管、加热器、材铸件、法兰管
- 主营：三癸基铝、甲氧苯基、磺胺曲沙唑、17746-77-9、625392-06-5、1423716-55-5、1547041-34-8、8-二羟基萘、4-氯嘧啶盐酸盐、三十二烷基铝、甲氧基苯甲酸
- 主营：苯肼、氯甲基苯乙烯、无水氯化锂、4-二氢吡喃、4-溴靛红、丙酰乙酸甲酯、邻硝基苯磺酰氯、碘甲烷、亚磷酸三苯酯、苯并噻唑、苄胺、苯基锂、叔丁醇钾、三丁基膦、四羟基二硼
- 主营：甘氨酸、阻燃剂、胶黏剂、3282-24-4、2768-02-7、7377-08-4、4865-84-3、5471-63-6、4355-11-7、蒽甲酸、热熔胶、退除剂、嘧菌酯、中性红、肉桂醛、退镍液、乙氧基、增弹剂、环氧胶、阻燃毯、亮氨酸、抛光盐、甲基橙、戊二酸、插入管
- 主营：二乙基、仲辛酮、阻燃剂、二氯吡啶、溴磷松、玉米素、基嘧啶、特乐酯、多果定、阿螨特、甲硫基、氮化镨、草除灵、聚合物、橙叶油、灭虫隆、三甲胺、敌螨普、育畜磷、禾草灵、溶剂绿、聚甘油、惕格酸、碳酸镍、肉桂醛、分散蓝
- 主营：二乙基、黄棕6gd、异戊酯、二氯吡啶、草酸镍、草酸镱、香叶酯、赤松素、硫化钇、硫酸锂、锡酸钠、氯苯基、甲硫基、硫化黑、精氨酸、cnidimola、甘氨酰、平平加、溴喹啉、地衣酸、松脂素、锑酸钠、氟苯肼、硼酸盐、氯吡唑、硼酸锌
- 主营：回收松香、回收油漆、回收石蜡、回收二氯吡啶、回收钛白粉、回收抗氧剂、回收薄荷脑、回收固化剂、回收溶剂油、回收氧化锌、回收珠光颜料、回收聚乙烯醇、回收染料颜料、回收各种溶剂、回收过期油漆、上门回收碳黑、回收各种树脂、回收水性色浆、回收橡胶助剂、回收玉米淀粉、回收化工原料、回收塑料助剂、回收染料中间体、回收聚醚多元醇
- 主营：回收油漆、回收化工原料、回收抗氧剂、回收二氯吡啶、回收促进剂、回收防老剂、回收钛白粉、回收氧化锌、回收硬脂酸锌、回收硬脂酸、回收硬脂酸钙、回收柠檬酸、回收柠檬酸钠、回收树脂、回收醇酸树脂、回收涂料、回收助剂、回收橡胶、回收日化原料、回收石蜡、回收废蜡、回收废料、回收颜料、回收染料、回收脂肪酸、回收表面活性剂
- 主营：回收珠光片、回收分子筛、回收戊二醇、回收二氯吡啶、回收乳胶漆、回收纤维素、回收氟碳漆、回收脂肪酸、回收弹性体、回收中间漆、回收磷酸锌、回收地板蜡、回收抗氧剂、回收稳定剂、回收丁香油、回收滑石粉、回收渗透剂、回收废甘油、回收丙二醇、回收凡士林、回收黑松香、回收真石漆、回收脱镍粉、回收结冷胶、回收环氧漆、回收维生素