2,3,7,7,8,8-Hexachlorodibenzo-p-dioxin

Updated: 2026-09-15

Overview

2,3,7,7,8,8-Hexachlorodibenzo-p-dioxin (HxCDD) is a chlorinated dioxin compound that belongs to the group of polychlorinated dibenzo-p-dioxins (PCDDs). These compounds are known for their high toxicity and persistence in the environment. HxCDD is primarily used in scientific research to study the effects of dioxins on human health and ecosystems. Due to its structural similarity to other dioxins, HxCDD is often investigated for its potential carcinogenic and endocrine-disrupting properties. It is not used in industrial applications but is significant in environmental monitoring and toxicology studies.

Physical and Chemical Properties

HxCDD is a white to off-white crystalline solid with a molecular weight of 390.86 g/mol. It is insoluble in water but dissolves readily in organic solvents such as benzene and dichloromethane. The compound is highly stable and resistant to degradation, making it a persistent environmental pollutant. Its chemical structure consists of two benzene rings connected by two oxygen atoms, with six chlorine atoms substituted at the 2,3,7,7,8,8 positions. This configuration contributes to its high toxicity and bioaccumulation potential in living organisms.

Main Applications

HxCDD is primarily used in research settings to study the toxicological effects of dioxins. It serves as a model compound for understanding the mechanisms of dioxin toxicity, including its impact on the aryl hydrocarbon receptor (AhR) pathway. Researchers also use HxCDD to assess environmental contamination levels and the effectiveness of remediation strategies. In industrial contexts, HxCDD is not intentionally produced but may appear as a byproduct in chemical manufacturing processes involving chlorinated compounds. Its presence is closely monitored in environmental samples to ensure compliance with regulatory standards.

Safety and Storage

Due to its high toxicity, HxCDD must be handled with extreme caution. Personnel should use appropriate personal protective equipment (PPE), including gloves, lab coats, and respiratory protection, to minimize exposure. Work with HxCDD should be conducted in a fume hood or other controlled environments to prevent inhalation or skin contact. Storage conditions for HxCDD require a cool, dry, and well-ventilated area, away from light and moisture. Containers should be tightly sealed and labeled with hazard warnings. Spills must be managed using specialized procedures to avoid environmental release.

B2B Procurement Guide

When procuring HxCDD for research or analytical purposes, buyers should prioritize suppliers with a proven track record of compliance with safety and environmental regulations. Certificates of analysis (CoA) should be requested to verify the compound's purity and identity. Given the compound's hazardous nature, transportation and handling must comply with international hazardous materials regulations. Buyers should also consider the availability of technical support and disposal services from the supplier to ensure safe and compliant use.