Overview
2,3-Dibromopyridine is a brominated derivative of pyridine, characterized by two bromine atoms at the 2- and 3-positions of the heterocyclic ring. It serves as a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical manufacturing. The compound is synthesized through direct bromination of pyridine or via halogen exchange reactions. Its reactivity stems from the electron-withdrawing effect of bromine atoms, making it valuable for palladium-catalyzed cross-coupling reactions like Suzuki or Stille couplings.
Physical and Chemical Properties
2,3-Dibromopyridine appears as a white to off-white crystalline solid with a molecular weight of 236.89 g/mol. It exhibits moderate solubility in polar organic solvents but low solubility in water, aligning with its lipophilic nature. Key chemical properties include its stability under inert conditions and reactivity as an electrophile in substitution reactions. The bromine atoms can be selectively replaced via metal-catalyzed transformations, enabling the synthesis of complex pyridine derivatives for drug discovery.
Main Applications
In pharmaceuticals, 2,3-dibromopyridine is a precursor for active ingredients in antiviral and anticancer drugs. Its bromine sites allow modular derivatization to create targeted molecular scaffolds. The agrochemical industry employs it in synthesizing herbicides and fungicides. Additionally, it serves as a ligand precursor in catalysis and a reagent in materials science for constructing conjugated systems in organic electronics.
Safety and Storage
As a brominated compound, 2,3-dibromopyridine requires careful handling. It is classified as harmful (H302/H312/H315) and may cause respiratory irritation (H335). Always use nitrile gloves, safety goggles, and respiratory protection in poorly ventilated areas. Storage recommendations include airtight containers under nitrogen or argon to prevent degradation. Compatibility with common lab materials like glass and PTFE makes it suitable for standard chemical storage cabinets.
B2B Procurement Guide
When sourcing 2,3-dibromopyridine, prioritize suppliers with ISO-certified manufacturing facilities. Key specifications to confirm include HPLC purity (typically ≥98%), residual solvent levels, and heavy metal content. Bulk procurement (1kg+) often reduces unit costs by 20-30%. Consider regional logistics—shipments may require hazardous material documentation due to bromine content. Sample testing for reactivity in your specific application is advised before large-scale purchases.
Related Manufacturers
- 主营：聚苯胺、脯氨酸甲酯盐酸盐、苄基三甲基氯化铵
- 主营：化学试剂、氯金酸、卡尔费休、13922、乙醇、异丙醇、药用辅料、依地酸钙钠、碳酸钠、盐酸氨丁三醇、龙胆酸、枸橼酸钠、甲醇、氢氧化钠、钴锰催化剂、硫酸锰、乙腈、色谱试剂、助剂、指示剂、醋酸锰、醋酸钴、氨丁三醇、尿素、硼酸
- 主营：阻燃剂、乙酸镍、乙酸镝、二溴吡啶、硫酸锂、硫酸锶、溴氨酸、香茅醇、肌氨酸、锂电池、四氢萘、磷酸铬、碳酸镁、碳酸镍、防冻剂、磷酸铝、叔丁醇、氟苯基、浮选剂、稀释剂、羟乙基、去除剂、庚二酸、除磷剂、十八烯、蛋白酶
- 主营：DMF、DMAC、二丙酮醇、91872、四甲基胍、马来酸酐、丙二醇、乙二醇、甲酸、甲醇、十二醇、柠檬酸、己二醇、甘油、四氢呋喃、碳酸丙烯酯、吐温、无水氯化钙、乙酸乙酯、氢氧化钠、二乙醇胺、司盘、过硫酸钠、氧化钙、氯化钾
- 主营：23、白僵菌素、薯蓣皂苷
- 主营：全氟三丁胺、木质素、吉氏色素
- 主营：杜仲素、对位酯、丙烯酸酯、23、二氧化硫脲、乙基麦芽酚、饲料添加剂、油酸基硬脂酸、二苯基硅二醇
- 主营：麦芽糖酸、苯氧基环磷腈、甲巯基四氮唑
- 主营：甘氨酸、甘氨酰、阻燃剂、醇酯-12、甲醇钠、蒽甲酯、十八酸、溴壬烷、肉桂醇、葱油醇、肉桂醛、异丁酯、赖氨酸、叔丁醇、多佐胺、醛试剂、乙氧基、脯氨酸、牛胆粉、癸酸酯、化合物、氟苯基、敏材料、氨酰胺、扁油酸
- 主营：硼酸酐、阻聚剂、己二酸、26、氯化锂、发泡剂、乙二醇、醋酸铜、硅酸钠、正癸醇、新癸酸、环烷油、腰果酚、十二醇、酒石酸、碳酸锂、三甘醇、油菜酸、二甘醇、碳酸钾、甲酸钠、硅酸镁、棕榈油、6-氯嘌呤、微晶石蜡、磷酸一铵
- 主营：二甲基亚砜、乙二醇、丙二醇、25、DMAC
- 主营：甜菊糖、氯乙酰、二乙苯、4316-73-8、4861-19-2、1192-62-7、7783-40-6、8002-74-2、7782-61-8、2842-44-6、酞菁绿、阻燃剂、二戊烯、单甲醚、硫酸锂、大理石、羊脂酸、磷酸氢、龙脑油、聚甘油、二聚酸、戊二醇、聚醚f68、磺化油、1310-58-3
- 主营：聚乙烯胺、烯丙基磺酸钠、分析标准品、糖精钠 128-44-9、70693-62-8 过硫酸氢钾、水杨酸钠 54-21-7、硫化钴 12013-10-4、催化剂及助剂
- 主营：侧柏叶油、当归提取物、益智仁精油、25、羟丙基硅油、侧柏叶精油、茴香提取液、墨旱莲提取物、接骨木提取液
- 主营：棕榈酸、乙酸铋、异喹啉、2-乙二硫醇、3-丙烷磺内酯、胶粘剂、丙烯酸酯、化学试剂、分析试剂、透明液体、二乙二醇、光引发剂、岩白菜素、对甲苯磺酸、苯甲酸苄酯、偏苯三酸酐、六氟异丙醇、纳米氧化铽、六氟磷酸铯、表面活性剂、蓖麻醇酸锌、乙基纤维素、荧光指示剂、4-二氟苄溴|、丙烯酸羟乙酯