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2-Pyridine

Updated: 2026-07-19

Overview

2-Pyridyl, also known as pyridin-2-yl, is a heterocyclic organic compound derived from pyridine. It is widely used in the chemical industry as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Its reactivity makes it valuable in coordination chemistry, where it acts as a ligand. Due to its versatile nature, 2-pyridyl is commonly employed in research and industrial applications. It is particularly useful in the development of complex molecules, including those used in medicinal chemistry and material science.

Physical and Chemical Properties

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2-Pyridyl is a colorless to pale yellow liquid with a characteristic odor. It has a molecular weight of 79.10 g/mol and a density of approximately 0.98 g/cm³. The compound is soluble in most organic solvents, which makes it easy to handle in laboratory and industrial settings. Its boiling point is around 115-118 °C, and it is highly reactive, particularly in the presence of oxidizing agents. This reactivity is leveraged in various chemical reactions, including those involving metal coordination and catalysis.

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Main Applications

2-Pyridyl is primarily used as an intermediate in the pharmaceutical industry, where it is incorporated into active pharmaceutical ingredients (APIs). It is also a key component in the synthesis of agrochemicals, such as pesticides and herbicides. In addition to its role in pharmaceuticals and agrochemicals, 2-pyridyl is used in organic synthesis to create complex molecules. Its ability to act as a ligand in coordination chemistry makes it valuable in the development of catalysts and other specialized chemicals.

Safety and Storage

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Handling 2-pyridyl requires caution due to its reactivity and potential health hazards. Proper personal protective equipment (PPE), including gloves and goggles, should be worn to avoid skin contact and inhalation. The compound should be stored in a cool, dry place away from oxidizers and other reactive substances. In case of exposure, immediate medical attention is recommended. Safety data sheets (SDS) provided by the supplier should be consulted for detailed handling and emergency procedures.

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B2B Procurement Guide

When procuring 2-pyridyl, it is essential to verify the purity and quality of the product. Reputable suppliers should provide certificates of analysis (CoA) to confirm the compound's specifications. Pricing can vary significantly based on quantity and supplier, so obtaining multiple quotes is advisable. Bulk purchases may offer cost advantages, but storage and handling requirements should be considered. Establishing long-term relationships with reliable suppliers can ensure consistent quality and timely delivery.

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