Overview
2-Propanol-d8, also known as deuterated isopropanol, is a deuterated form of isopropanol where all hydrogen atoms are replaced by deuterium. This compound is primarily used as a solvent in nuclear magnetic resonance (NMR) spectroscopy due to its ability to provide a deuterium lock signal. Its high isotopic purity makes it invaluable in research and pharmaceutical applications where precise molecular analysis is required. Deuterated solvents like 2-Propanol-d8 are essential in NMR spectroscopy because they minimize interference from hydrogen signals in the sample. This allows for clearer and more accurate spectral data, which is critical in structural elucidation and chemical analysis.
Physical and Chemical Properties
2-Propanol-d8 is a colorless liquid with a molecular weight of 68.15 g/mol. It has a density of 0.89 g/cm³ and is miscible with water and most organic solvents. The compound has a melting point of -88.5°C and a boiling point of 82.5°C, similar to its non-deuterated counterpart. One of the key properties of 2-Propanol-d8 is its high isotopic purity, typically exceeding 99%. This ensures minimal interference from protiated species in sensitive analytical techniques. The compound is also flammable and should be handled with care to avoid ignition sources.
Main Applications
The primary application of 2-Propanol-d8 is in NMR spectroscopy, where it serves as a deuterated solvent. It is particularly useful in proton NMR studies, as it provides a deuterium lock signal essential for stabilizing the magnetic field during experiments. In addition to NMR, 2-Propanol-d8 is used in pharmaceutical research for labeling studies and metabolic tracing. Its ability to replace hydrogen with deuterium can slow down certain metabolic processes, making it valuable in drug development and pharmacokinetic studies.
Safety and Storage
2-Propanol-d8 is a flammable liquid and should be stored in a cool, dry place away from open flames and heat sources. Proper ventilation is recommended to prevent the accumulation of vapors. Personal protective equipment, such as gloves and safety goggles, should be worn when handling the compound. In case of spillage, absorb the liquid with an inert material and dispose of it according to local regulations. Avoid direct contact with skin or eyes, and seek medical attention if irritation occurs. Always refer to the material safety data sheet (MSDS) for detailed safety instructions.
B2B Procurement Guide
When procuring 2-Propanol-d8, it is essential to verify the isotopic purity, typically specified as 99% or higher. Suppliers should provide certificates of analysis to confirm the purity and quality of the product. Storage conditions should also be considered, as improper storage can degrade the compound. Bulk purchases may offer cost advantages, but ensure that the supplier can meet the required specifications and delivery timelines. Pricing can vary significantly based on purity and quantity, with reference prices ranging from approximately $200 to $500 per liter. Always compare multiple suppliers to ensure competitive pricing and reliable quality.
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