Overview
2-Nitrobenzamide is an organic compound belonging to the nitrobenzamide family. It is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound is characterized by its nitro group attached to the benzene ring, which imparts specific reactivity useful in chemical transformations. In industrial settings, 2-nitrobenzamide is valued for its role in producing more complex molecules. Its synthesis typically involves the nitration of benzamide or related precursors. The compound's stability and solubility profile make it suitable for various chemical processes.
Physical and Chemical Properties
2-Nitrobenzamide appears as a yellow to pale brown crystalline powder with a melting point of approximately 160-162°C. It is soluble in common organic solvents such as ethanol and acetone but has limited solubility in water. The nitro group contributes to its polarity and reactivity, making it useful in electrophilic substitution reactions. The compound is relatively stable under standard conditions but may decompose when exposed to high temperatures or strong acids/bases. Its molecular weight is 166.13 g/mol, and it does not exhibit significant volatility at room temperature.
Main Applications
The primary application of 2-nitrobenzamide is as an intermediate in pharmaceutical synthesis. It is used to produce active pharmaceutical ingredients (APIs) and other specialty chemicals. The nitro group can be reduced to an amine, enabling further functionalization. In agrochemical production, 2-nitrobenzamide serves as a precursor for herbicides and pesticides. Its reactivity allows for the creation of compounds with specific biological activity. Additionally, it is used in research laboratories for studying nitroaromatic compounds and their transformations.
Safety and Storage
2-Nitrobenzamide should be handled with care to avoid exposure. Inhalation, ingestion, or skin contact can cause irritation or adverse health effects. Proper personal protective equipment (PPE), such as gloves and goggles, is recommended when working with this compound. Storage should be in a cool, dry place, away from direct sunlight and moisture. Containers must be tightly sealed to prevent contamination or degradation. In case of spills, absorb with inert material and dispose of according to local regulations.
B2B Procurement Guide
When procuring 2-nitrobenzamide, buyers should verify the CAS number (610-15-1) to ensure product authenticity. Purity specifications, typically 98% or higher, should be confirmed with the supplier. Requesting a Material Safety Data Sheet (MSDS) and Certificate of Analysis (COA) is essential for quality assurance. Suppliers should be evaluated based on their reliability, production capacity, and compliance with regulatory standards. Bulk purchases may offer cost advantages, but storage conditions must be considered to maintain product integrity.
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