Overview
2-Methyl-7-hydroxyquinoline is an organic compound belonging to the quinoline family. It features a methyl group at the 2-position and a hydroxyl group at the 7-position of the quinoline ring. This structural configuration gives it unique chemical properties, making it valuable in various industrial applications. Quinoline derivatives like 2-methyl-7-hydroxyquinoline are widely studied due to their biological activities and material properties. The compound is primarily synthesized through Skraup or Doebner-Miller reactions followed by selective hydroxylation. Its versatility has led to adoption in pharmaceutical synthesis and specialty chemicals.
Physical and Chemical Properties
The compound appears as an off-white to light yellow crystalline powder with a characteristic quinoline odor. It exhibits weak acidity due to the phenolic hydroxyl group, with a pKa around 9-10. The methyl substitution increases its lipophilicity compared to unsubstituted hydroxyquinolines. 2-Methyl-7-hydroxyquinoline demonstrates notable fluorescence under UV light, with emission typically in the blue-green region. This property makes it useful in optical applications. The compound shows good thermal stability below 200°C, but may decompose at higher temperatures. Its solubility profile favors organic solvents over water.
Main Applications
In pharmaceuticals, 2-methyl-7-hydroxyquinoline serves as a key intermediate for antimalarial drugs and other bioactive compounds. Its quinoline core structure is pharmacologically significant, often incorporated into molecules with antibacterial or anticancer properties. The compound finds use in agrochemicals as a building block for fungicides and pesticides. Material scientists employ it in developing fluorescent dyes for sensors and OLED materials. Industrial applications include metal corrosion inhibitors, particularly in acidic environments where quinolines demonstrate protective effects.
Safety and Storage
As with many quinoline derivatives, 2-methyl-7-hydroxyquinoline requires careful handling. It may cause skin and eye irritation upon contact, and inhalation of dust should be avoided. Appropriate personal protective equipment including gloves, goggles and respiratory protection is recommended when handling the powder form. For storage, maintain the material in tightly sealed containers under inert atmosphere if possible. The compound is relatively stable at room temperature but may degrade over time when exposed to light or moisture. Storage areas should be well-ventilated and away from incompatible substances such as strong oxidizers.
B2B Procurement Guide
When sourcing 2-methyl-7-hydroxyquinoline, buyers should prioritize suppliers with demonstrated expertise in quinoline chemistry. Key procurement considerations include purity specifications (typically 98% or higher), batch-to-batch consistency, and proper documentation including certificates of analysis. For industrial-scale purchases, evaluate the supplier's production capacity and quality control processes. Request samples for in-house testing before large orders. Pricing varies significantly based on purity and order volume, with bulk purchases (100kg+) often attracting substantial discounts. Lead times may range from 2-6 weeks depending on supplier inventory and production schedules.
Related Manufacturers
- 主营：聚乙烯亚胺、三甘醇二异辛酸酯3G8、三硫代碳酸钠40%、TS-1钛硅分子筛、5-甲基靛红、六氯环三磷腈、烷基苯磺酸酯、苯基次磷酸钠、甲巯咪唑、吡啶硫酮锌、焦磷酸哌嗪、热敏材料、油酸甲酯、曲酸
- 主营：二甲基亚砜、乙二醇、丙二醇、DMAC
- 主营：甜菊糖、氯乙酰、二乙苯、4316-73-8、4861-19-2、1192-62-7、7783-40-6、8002-74-2、7782-61-8、2842-44-6、1310-58-3、酞菁绿、阻燃剂、二戊烯、单甲醚、硫酸锂、大理石、羊脂酸、磷酸氢、龙脑油、聚甘油、二聚酸、戊二醇、聚醚f68、磺化油
- 主营：2-十一酮、乙酸龙脑酯、聚苯乙烯磺酸钠、乙基黄原酸钾
- 主营：乙酸镁、并噻吩、三蝶烯、α-氟萘、2223-82-7、硫酸锂、二乙烯、硫酸锶、肌氨酸、嘧菌酯、碳酸镁、新癸酸、赖氨酸、多佐胺、咯菌腈、乙氧基、茚三酮、咖啡酸、氟苯基、羟乙基、异恶唑、喹啉黄、庚二酸、虫酰肼、吡咯并
- 主营：硼酸酐、阻聚剂、己二酸、6-氯嘌呤、氯化锂、发泡剂、乙二醇、醋酸铜、硅酸钠、正癸醇、新癸酸、环烷油、腰果酚、十二醇、酒石酸、碳酸锂、三甘醇、油菜酸、二甘醇、碳酸钾、甲酸钠、硅酸镁、棕榈油、微晶石蜡、磷酸一铵
- 主营：氯菊酯、转移剂、聚酯树脂、二甲氧基、驱蚊原液、食品香料、缩水甘油酯、蚊香增效剂、丙烯酸缩水、环氧稀释剂、硅烷偶联剂、超疏水材料、对甲氧基苯酚、对羟基苯甲醚、乙烯基双封头、苯基缩水甘油醚
- 主营：生物活性玻璃、全氟三丁胺、花椒麻素、2-十一酮、二羟基丙酮、光引发剂、乙酸龙脑酯、羟基磷灰石
- 主营：荧光素酶、血管紧张素转化酶、乳酸氧化酶、117、脱氧核糖核酸酶1型、乙酰胆碱酯酶、硫酸软骨素ABC酶、肝素酶
- 主营：甲基、白僵菌素、薯蓣皂苷
- 主营：中间体、尿囊素、肉豆蔻酸异丙酯、椰油基三甲基氯化铵、烯丙基羟乙基醚、苄基三乙基氯化铵、马来酸、乙酰苯肼
- 主营：医药中间体、材料中间体、化工原料、甲基、试剂
- 主营：联吡啶、丁烯酸、阻燃剂、α-氨基、10-蒽二、3382-63-6、二苯胺、胶黏剂、氨基芴、十八酸、乙二酸、肉桂醇、王浆酸、异丁酮、溴化鏻、乙氧基、豆甾醇、碘乙烷、二乙醇、氟苯基、稀释剂、羟乙基、氯甲酚、桂皮醇、桂皮醛
- 主营：邻苯甲酰苯甲酸、偶联剂、硅烷偶联剂、6-萘二羧酸、kh-602、十八硫醇、碳酸铯、胆酸钠、脱氧胆酸钠、去氧胆酸钠、去氢胆酸、溴代丙二醛、茶籽油、聚钨酸钠、氰乙酸甲酯、沙棘籽油、乙酰氧基氮杂环丁酮、桔子油、亚麻油、柠檬桉醇、芳樟醇、二氟苯胺、萃取剂、乙酰氧基苯乙烯
- 主营：杂环化合物、丙烯酸系列