2-Iodobenzonitrile[2]
Overview
2-Iodobenzonitrile is an organic compound featuring an iodine atom and a nitrile group on a benzene ring. It serves as a key intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. The compound is valued for its reactivity, enabling transformations such as cross-coupling reactions. Its molecular structure makes it suitable for constructing complex molecules, including active pharmaceutical ingredients (APIs).
Physical and Chemical Properties
2-Iodobenzonitrile appears as a white to pale yellow crystalline solid with a melting point of 60-62°C. It is soluble in common organic solvents but insoluble in water, reflecting its hydrophobic nature. The iodine substituent enhances its reactivity in palladium-catalyzed coupling reactions, while the nitrile group can be further functionalized. Stability under standard conditions makes it suitable for laboratory and industrial use.
Main Applications
This compound is primarily used in the synthesis of pharmaceuticals, where it acts as a building block for drugs targeting neurological and metabolic disorders. Its iodine moiety facilitates Suzuki and Sonogashira couplings. In agrochemicals, it contributes to the development of herbicides and pesticides. Specialty chemical manufacturers also employ it for creating dyes and ligands for catalysis.
Safety and Storage
2-Iodobenzonitrile is harmful if ingested or inhaled and may cause skin irritation. Proper personal protective equipment (PPE), including gloves and goggles, is essential during handling. Store in a tightly sealed container in a cool, dry, and well-ventilated area. Avoid exposure to light and moisture to prevent degradation. Dispose of waste in compliance with local regulations.
B2B Procurement Guide
When procuring 2-Iodobenzonitrile, prioritize suppliers with ISO or GMP certifications to ensure quality. Request certificates of analysis (CoA) for purity and impurity profiles. Bulk purchases may offer cost advantages, but verify storage compatibility. Lead times can vary; plan procurement to align with project timelines. For reference, prices range from $50-$200 per gram based on quantity and purity.
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