Overview
2-Iodo-1-phenylethanone is an organic iodide compound primarily used as an intermediate in chemical synthesis. It is a derivative of acetophenone, where the hydrogen atom at the second position is replaced by an iodine atom. This modification enhances its reactivity, making it valuable in various organic transformations. The compound is widely utilized in pharmaceutical research and agrochemical production due to its ability to introduce iodine into molecular structures. Its synthesis typically involves the iodination of acetophenone under controlled conditions to ensure high purity and yield.
Physical and Chemical Properties
2-Iodo-1-phenylethanone appears as a pale yellow to white crystalline powder with a distinct odor. It is sensitive to light and should be stored away from direct sunlight to prevent decomposition. The compound has a melting point range of 54-56°C, which is relatively low compared to similar aromatic ketones. Chemically, 2-iodo-1-phenylethanone is reactive towards nucleophiles and can participate in substitution reactions. It is soluble in common organic solvents like ethanol and acetone but has limited solubility in water. The presence of the iodine atom makes it a useful reagent for further functionalization in synthetic chemistry.
Main Applications
The primary application of 2-iodo-1-phenylethanone is as a building block in pharmaceutical synthesis. It serves as an intermediate for the production of various drugs, including anti-inflammatory and antimicrobial agents. The iodine moiety allows for further derivatization, enabling the creation of complex molecular structures. In addition to pharmaceuticals, this compound is used in agrochemicals to develop pesticides and herbicides. Its reactivity makes it suitable for coupling reactions and cross-coupling processes, which are essential in modern organic synthesis. Research laboratories also employ it for studying reaction mechanisms and developing new synthetic pathways.
Safety and Storage
Handling 2-iodo-1-phenylethanone requires strict safety precautions due to its potential health hazards. It is harmful if swallowed or inhaled and can cause skin and eye irritation. Personal protective equipment, including gloves, goggles, and lab coats, should be worn when working with this chemical. Proper storage is crucial to maintain its stability. The compound should be kept in a cool, dry place, away from light and moisture. Containers must be tightly sealed to prevent exposure to air, which could lead to degradation. In case of spills, immediate cleanup with appropriate absorbents is recommended to minimize risks.
B2B Procurement Guide
When procuring 2-iodo-1-phenylethanone, buyers should prioritize suppliers who provide detailed documentation, including certificates of analysis (CoA) and safety data sheets (SDS). Purity levels, typically ranging from 95% to 99%, should be verified to ensure the compound meets specific application requirements. Bulk purchases may offer cost advantages, but storage capacity and shelf life should be considered. Buyers are advised to compare prices from multiple suppliers, as costs can vary significantly based on quantity and purity. Additionally, inquire about packaging options to ensure safe transportation and handling.
Related Manufacturers
- 主营：聚苯胺、脯氨酸甲酯盐酸盐、苄基三甲基氯化铵
- 主营：聚乙烯亚胺、三甘醇二异辛酸酯3G8、三硫代碳酸钠40%、TS-1钛硅分子筛、5-甲基靛红、六氯环三磷腈、烷基苯磺酸酯、苯基次磷酸钠、甲巯咪唑、吡啶硫酮锌、焦磷酸哌嗪、热敏材料、油酸甲酯、曲酸
- 主营：阻燃剂、乙酸镍、乙酸镝、12、硫酸锂、硫酸锶、溴氨酸、香茅醇、肌氨酸、锂电池、四氢萘、磷酸铬、碳酸镁、碳酸镍、防冻剂、磷酸铝、叔丁醇、氟苯基、浮选剂、稀释剂、羟乙基、去除剂、庚二酸、除磷剂、十八烯、蛋白酶
- 主营：乙二醇、二甲基亚砜、丙二醇、4-丁二醇、精对苯二甲酸、己二酸、聚乙烯醇、聚乙二醇、木质素、甘油、三甘醇、己内酰胺、叔十二硫醇、白油、对苯二甲酸二甲酯
- 主营：杀菌剂、椰子油、印染剂、碘化锂、阻燃剂、油酸锌、润湿剂、硫酸铯、催化剂、粘合剂、乳化剂、草酸锰、硫酸锂、石英砂、绝缘油、茶皂素、防腐剂、醋酸镁、锂电池、培养基、蒸馏水、硬脂酸、塑化剂、草酸钾、磷酸铁
- 主营：杜仲素、对位酯、丙烯酸酯、2氯4硝基吡啶、二氧化硫脲、乙基麦芽酚、饲料添加剂、油酸基硬脂酸、二苯基硅二醇
- 主营：异丙醇、冰醋酸、化工原料、正庚烷、甲基环己烷、乙二醇、苯酚、江苏异丙醇、江苏化工原料、工业吡啶、工业苯酚、正丁醇、MIBK、无水乙醇、正己烷
- 主营：阻燃剂、催化剂、水杨酸、二苯基、酰亚胺、正磷酸、烟酰胺、曲酸粉、氯化锌、异丙醇、化妆品、初油酸、脂肪醇、生石灰、甲基异、碳酸锌、碳酸锂、活性炭、乙二胺、三氮唑、着色剂、环己酮、防冻液、抗氧剂、亚磷酸
- 主营：全氟聚醚二醇、全氟三丁胺、聚硅氮烷、1122、特种硅油、特种硅树脂
- 主营：236117、全氟三丁胺、木质素、吉氏色素
- 主营：离子液体、咪唑、催化剂、5-二甲基吡唑、阻燃剂、正丁醇锆、四氟硼酸锂、香兰基丁醚、氟化物、全氟辛基三甲氧基硅烷、丙酮肟、双酚E型氰酸酯、叔丁基乙烯基醚、钯碳催化剂、钛硅分子筛、硫酸烟酰苯胺、丙酮缩氨基硫脲
- 主营：甲酸镍、水苏糖、阻燃剂、5122、柠檬醛、西瓜酮、氢醌酯、卡必醇、消泡剂、磷酸铁、肉桂醇、肉桂醛、碳酸镉、磷酸铝、银墨水、椰油胺、封装胶、化合物、桦木油、稀释剂、羟乙基、乙硫氮、润肤剂、球虫酯、矮壮素、异龙脑
- 主营：全氟三丁胺、二苄叉山梨醇、六氟丙烯二聚体、邻碘溴苯、六氟环氧丙烷二聚体、异丙醇铝、纳米勃姆石、二异戊基硫醚、隐色结晶紫、邻菲罗啉
- 主营：架桥剂、端羧基液体丁腈橡胶、苯乙烯磷酸、YW100 锂萃取剂、10-羟基癸酸、β-磷酸三钙、1-乙炔基环已醇、肉豆蔻酸镁、硬脂酸钴、全氟三丁胺、乙烯基磷酸二乙酯、磷酸锰铁锂、十一烯酸、钨酸铝、间二异丙苯、锂硅合金、溴甲酚绿、生物活性玻璃、溴代海因树脂颗粒、红铝、龙涎酮、原丁酸三甲酯
- 主营：甘氨酸、水苏糖、阻燃剂、1680-21-3、硫酸锌、硫酸锆、硫酸锂、硫酸锶、硫酸锰、铝酸锌、牛磺酸、褪黑素、磷酸铁、丙酸铵、苏云金、碳酸镁、麝香酮、肉桂醛、磷酸铝、王浆酸、椰油胺、赖氨酸、增塑剂、浸膏粉、乙氧基