Overview
2-α-Hydroxyursolic Acid is a naturally occurring pentacyclic triterpenoid compound derived from various medicinal plants, including those from the Ericaceae and Lamiaceae families. As a structural derivative of ursolic acid, it has gained attention in pharmaceutical research due to its potential bioactive properties. The compound is particularly noted for its hydroxyl group at the C-2 position, which distinguishes it from the more common ursolic acid. This structural modification may enhance certain biological activities, making it valuable for drug discovery and development processes.
Physical and Chemical Properties
2-α-Hydroxyursolic Acid typically presents as a white to off-white crystalline powder with a melting point range of 280-285°C (with decomposition). Its molecular structure features five fused rings characteristic of triterpenoids, with hydroxyl groups at positions 2α, 3β and a carboxyl group at C-17. The compound demonstrates moderate solubility in polar organic solvents like methanol and ethanol, with limited solubility in water. Its stability is generally good when stored properly, though it may degrade under prolonged exposure to light, heat, or moisture. The presence of multiple functional groups makes it amenable to various chemical modifications.
Main Applications
In pharmaceutical research, 2-α-Hydroxyursolic Acid serves as a valuable intermediate for developing novel therapeutic agents. Studies suggest potential applications in anti-inflammatory, anticancer, and metabolic disorder treatments, though clinical applications remain investigational. The compound also finds use in cosmetic formulations, particularly in anti-aging products, due to its antioxidant properties. Additionally, it serves as a reference standard in analytical chemistry for quality control of plant extracts and herbal medicines containing related triterpenoids.
Safety and Storage
While not classified as highly toxic, 2-α-Hydroxyursolic Acid should be handled with standard laboratory precautions. Avoid inhalation of dust and direct skin contact. In case of exposure, wash affected areas thoroughly with water. For long-term storage, maintain the compound in tightly sealed containers under controlled conditions (2-8°C) with protection from light and moisture. Desiccants may be added to storage containers to prevent moisture absorption. Proper labeling should include hazard information and storage requirements.
B2B Procurement Guide
When sourcing 2-α-Hydroxyursolic Acid commercially, prioritize suppliers with demonstrated expertise in plant-derived compounds. Key considerations include purity verification (typically 95-98% by HPLC), batch-to-batch consistency, and comprehensive documentation including Certificates of Analysis. For research applications, smaller quantities (mg to g scale) are commonly available, while industrial-scale procurement may require custom synthesis arrangements. Lead times can vary significantly depending on supplier inventory and production schedules, so advance planning is recommended. Consider requesting samples for quality verification before large purchases.
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