Overview
2-Hydroxyphenetole, commonly referred to as guaethol, is a phenolic ether with a molecular formula of C8H10O2. It is widely utilized in the pharmaceutical and fragrance industries due to its aromatic properties and reactivity as an intermediate. The compound is synthesized through the etherification of catechol or similar phenolic compounds. As a versatile chemical, 2-hydroxyphenetole serves as a building block in organic synthesis, particularly in the production of cough suppressants and flavoring agents. Its CAS number (122-99-6) ensures precise identification in global trade and regulatory compliance.
Physical and Chemical Properties
2-Hydroxyphenetole is a colorless to pale yellow liquid with a characteristic aromatic odor. It has a boiling point of 245-247°C and a density of approximately 1.10 g/cm³. The compound is soluble in organic solvents like ethanol and ether but only slightly soluble in water. Its stability under normal storage conditions makes it suitable for industrial use, though it should be protected from strong oxidizers. The phenolic hydroxyl group in its structure contributes to its reactivity in synthesis processes, such as esterification or alkylation.
Main Applications
In the pharmaceutical industry, 2-hydroxyphenetole is a key intermediate for synthesizing guaifenesin, a common expectorant. It also finds use in fragrance formulations, imparting sweet, floral notes to perfumes and cosmetics. Additionally, it serves as a precursor in organic synthesis for producing dyes, resins, and other specialty chemicals. Its role in B2B supply chains is critical for manufacturers requiring high-purity intermediates for regulated end products.
Safety and Storage
2-Hydroxyphenetole is classified as an irritant, requiring handling with gloves, goggles, and proper ventilation. Prolonged exposure to skin or eyes may cause irritation, and inhalation should be avoided. Storage recommendations include keeping the compound in tightly sealed containers in a cool, dry place away from direct sunlight and oxidizers. Spills should be contained with inert absorbents and disposed of according to local regulations.
B2B Procurement Guide
When procuring 2-hydroxyphenetole, buyers should prioritize suppliers with certifications like ISO 9001 or GMP compliance to ensure quality. Key specifications to verify include purity (typically ≥98%) and the absence of contaminants. Bulk purchases may offer cost advantages, but storage capacity and shelf life must be considered. Request safety data sheets (SDS) and conduct audits for reliable supply chain partnerships. Prices vary based on quantity and market demand, commonly ranging between $50-$100/kg.
Related Manufacturers
- 主营：聚乙烯亚胺、三甘醇二异辛酸酯3G8、三硫代碳酸钠40%、TS-1钛硅分子筛、5-甲基靛红、烷基苯磺酸酯、苯基次磷酸钠、六氯环三磷腈、甲巯咪唑、吡啶硫酮锌、焦磷酸哌嗪、热敏材料、油酸甲酯、曲酸
- 主营：甲基丙烯酸十二酯、甲基丙烯酸十六酯、甲基丙烯酸十八酯、N-乙酰己内酰胺、N-异丙基丙烯酰胺、丙烯酸十二酯、丙烯酸十六酯、丙烯酸十八酯、V50引发剂、偶氮二异丁咪唑啉盐酸盐、硅烷偶联剂、双马来酰亚胺、马来酸酯、缩水甘油酯、缩水甘油醚、甲基咪唑、金属萃取剂
- 主营：甘氨酸、甘氨酰、阻燃剂、醇酯-12、氟苯基、甲醇钠、蒽甲酯、十八酸、溴壬烷、肉桂醇、葱油醇、肉桂醛、异丁酯、赖氨酸、叔丁醇、多佐胺、醛试剂、乙氧基、脯氨酸、牛胆粉、癸酸酯、化合物、敏材料、氨酰胺、扁油酸
- 主营：环戊酮、甲酸镍、阻燃剂、羟基苯乙醚、草酸镧、钼酸铵、催化剂、钒酸铋、溴氨酸、硝酸锆、碳酸镧、白僵菌、磷酸铁、钨酸酐、氟化镧、视黄醇、叔丁醇、杀螨剂、杀虫剂、醋酸钬、抗粘剂、氟化镥、肟菌酯、氢化钠、氯铂酸、氟化镁
- 主营：甲酸镍、水苏糖、阻燃剂、柠檬醛、西瓜酮、氢醌酯、卡必醇、消泡剂、磷酸铁、肉桂醇、肉桂醛、碳酸镉、磷酸铝、银墨水、椰油胺、封装胶、化合物、桦木油、稀释剂、羟乙基、乙硫氮、润肤剂、球虫酯、矮壮素、异龙脑
- 主营：聚丙烯酰胺、聚合氯化铝、片碱、羟基苯乙醚、纯碱、硫酸亚铁、磷酸、元明粉、乙二醇、工业盐、次氯酸钠
- 主营：硫化铵、氧化石蜡皂、选矿药剂、羟基苯乙醚、表面活性剂、阻燃剂、有机化合物、中间体、日用香精、树脂
- 主营：十六烷基磺酸钠、聚硅氧烷、新癸酸钕、医药中间体、巯基乙酸铵、甲氧基丙酮、表面活性剂、1.3环己二酮、三甲基溴化硫醚
- 主营：对二苯甲酸二肼
- 主营：液体聚硫橡胶、氮丙啶交联剂、异山梨醇二甲醚、氧化石蜡皂、水杨羟肟酸、乙二胺磷酸盐
- 主营：氧化石蜡皂、月桂酸钠、氮丙啶交联剂、苯乙烯磺酸钠、噻唑硫醇、尼龙酸二异丁酯、氧氯化锆、甲基丙烯酸丁酯、甲基丙烯酸十八酯、乙二胺磷酸盐
- 主营：香豆素、铃兰花、家居香氛、异丁酸苯酯、二苯并、邻氨基苯甲醇、L - 甲状腺素、52688-08-1、对甲苯磺酸、绿色香料、结晶玫瑰、理想香料、甲基硝基胍、溴代十四烷、a 碳酸酯齐聚物、99%纯度新铃兰醛、聚脱氧核糖核酸、鲑鱼精、脱氧核糖核酸、四水合氟化镍、蛋白胨、法尼醇、氰乙酸仲辛酯、乙酸肉桂酯、十六烷基三甲基溴化铵
- 主营：羟基苯乙醚、乙酰丙酮氧
- 主营：酰亚胺、异丙基、氨基丙基、苯甲醛、苯磺酸、cas-50-63-5、苯并三唑、氮杂苯并、磷酸二苯酯、试剂医药、化学醋酸、化学试剂、甲基硅基、盐酸羟胺、苄基丙酮、试剂化工、丙烯酰氯、甲基乙炔、二叔丁酯、化学碳酸钾、二酸二乙酯、酸二异丙酯、二咪唑羰基、中间体化工、医药中间体
- 主营：凉味剂、除氧剂、防老剂、氟甲基苯、2四油酸酯、柔顺剂、抗氧剂、保湿剂、珠光片、丙二酸钠、丙烯酸锌、异辛酸锌、十二烷基、优级福美钠、农药中间体、彩色显影剂、氢化蓖麻油、高效阻聚剂、固化促进剂、甲基乙二醇、优级有机硅、缓蚀阻垢剂、复合型乳液、氧基铝酸酯、三氟甲氧基