Overview
2-Hydroxynaringenin is a bioactive flavonoid derived from naringenin, a compound abundant in citrus fruits like grapefruits and oranges. It is synthesized through hydroxylation of naringenin, enhancing its biological activity. Research highlights its antioxidant and anti-inflammatory properties, making it a candidate for therapeutic and nutraceutical applications. Flavonoids like 2-hydroxynaringenin are studied for their role in mitigating oxidative stress and inflammation-related diseases. Its structural modifications may improve bioavailability compared to its parent compound, naringenin.
Physical and Chemical Properties
2-Hydroxynaringenin is a pale yellow crystalline powder with a molecular weight of 302.28 g/mol. It is stable under standard conditions but degrades upon prolonged exposure to light or high temperatures. The compound exhibits moderate solubility in organic solvents like ethanol and DMSO but is less soluble in water. Its melting point ranges between 180-185°C, indicative of its moderate thermal stability. Spectroscopic methods (e.g., NMR, IR) confirm its hydroxyl and methoxy functional groups, critical for its reactivity and biological effects.
Main Applications
In pharmaceuticals, 2-hydroxynaringenin is investigated for its potential in treating chronic inflammation, neurodegenerative diseases, and cancer due to its antioxidant mechanisms. It may also enhance the efficacy of existing drugs by modulating metabolic pathways. Nutraceutical formulations incorporate it for its purported health benefits, including cardiovascular protection and immune support. Cosmetic industries use it in anti-aging products for its ability to neutralize free radicals and reduce skin oxidative damage.
Safety and Storage
While 2-hydroxynaringenin is generally considered safe at low concentrations, high doses may cause cytotoxicity. Laboratory handling requires gloves, goggles, and ventilation to prevent inhalation or skin contact. Storage should be in airtight, light-resistant containers at temperatures below 25°C. Long-term stability is improved by desiccants to avoid moisture absorption, which can lead to degradation.
B2B Procurement Guide
Buyers should prioritize suppliers with transparent quality control, such as COA (Certificate of Analysis) for purity (≥95% by HPLC). Bulk procurement may offer cost advantages, but batch-to-batch consistency must be verified. Consider suppliers compliant with Good Manufacturing Practices (GMP) or ISO certifications. Lead times and scalability are critical for industrial applications, especially in pharmaceuticals.
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