2-Hydroxyflavanone

Updated: 2026-09-12

Overview

2-Hydroxyflavanone is a flavanone derivative characterized by a hydroxyl group at the 2-position of the flavanone structure. It serves as an intermediate in the synthesis of bioactive compounds and pharmaceuticals. Its structural similarity to other flavonoids grants it potential antioxidant and therapeutic properties, making it valuable in research and industrial applications. This compound is typically synthesized through organic reactions involving chalcone precursors or modifications of existing flavanones. Its purity and stability are critical for consistent performance in laboratory and commercial settings.

Physical and Chemical Properties

2-Hydroxyflavanone appears as a pale yellow to white crystalline powder with a melting point range of 180-185°C. It is soluble in polar organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), but exhibits limited solubility in water. The compound's stability under standard storage conditions makes it suitable for long-term use in research. Key chemical properties include its reactivity as a flavanone derivative, which allows for further functionalization in synthetic chemistry. The hydroxyl group at the 2-position enhances its participation in hydrogen bonding and metal coordination, relevant for catalytic or pharmacological studies.

Main Applications

In pharmaceuticals, 2-Hydroxyflavanone is explored as a precursor for drugs targeting oxidative stress-related diseases. Its antioxidant properties are studied for potential use in nutraceuticals and cosmetic formulations. The compound also serves as a building block in organic synthesis, particularly for flavonoid analogs. Industrial applications include its role as a reference standard in analytical chemistry and quality control for flavonoid-based products. Research institutions and chemical manufacturers are the primary users, emphasizing its niche but significant demand.

Safety and Storage

While 2-Hydroxyflavanone is not classified as highly hazardous, standard laboratory precautions are advised. Use gloves, goggles, and ventilation to avoid skin contact or inhalation. In case of exposure, rinse affected areas with water and seek medical advice if irritation persists. Storage requires protection from light, moisture, and extreme temperatures. Sealed containers in cool, dry environments (e.g., refrigerators or desiccators) are recommended to maintain stability. Shelf life typically extends to several years under optimal conditions.

B2B Procurement Guide

B2B buyers should prioritize suppliers with ISO certification or compliance with Good Manufacturing Practices (GMP). Key procurement criteria include purity (e.g., ≥98% by HPLC), batch consistency, and documentation like Certificates of Analysis (CoA). Bulk purchases (100g or more) often qualify for discounts, but sample testing is recommended for new suppliers. Lead times vary; specialized purities or custom packaging may require extended production schedules. International shipments should comply with chemical transportation regulations.