Overview
2'-Hydroxychalcone is an organic compound belonging to the chalcone family, characterized by a hydroxyl group at the 2' position of its aromatic ring. It is widely recognized for its role in pharmaceutical and biochemical research, particularly as a precursor in the synthesis of flavonoids and other bioactive compounds. Its molecular structure allows it to participate in various chemical reactions, making it a versatile intermediate in organic synthesis. The compound is primarily used in academic and industrial research settings to study its antioxidant and anti-inflammatory properties. Its ability to modulate biological pathways has sparked interest in potential therapeutic applications, though further research is needed to validate these uses.
Physical and Chemical Properties
2'-Hydroxychalcone appears as a yellow crystalline powder with a molecular weight of 224.26 g/mol. It has a melting point of approximately 92-94°C and is soluble in common organic solvents such as ethanol and dimethyl sulfoxide (DMSO), though its solubility in water is limited. The presence of the hydroxyl group enhances its reactivity, particularly in hydrogen bonding and chelation reactions. The compound's stability under standard conditions makes it suitable for storage in laboratory settings, provided it is kept away from light and moisture. Its UV-visible absorption spectrum is often studied to understand its electronic properties, which are relevant to its role in photochemical applications.
Main Applications
2'-Hydroxychalcone is predominantly used in pharmaceutical research, where it serves as a key intermediate in the synthesis of flavonoids and other polyphenolic compounds. These derivatives are investigated for their potential antioxidant, anti-inflammatory, and anticancer properties. The compound's ability to scavenge free radicals makes it a valuable tool in studying oxidative stress-related diseases. In addition to its biomedical applications, 2'-Hydroxychalcone is utilized in material science for the development of organic semiconductors and photostable dyes. Its structural versatility allows it to be incorporated into larger molecular frameworks, enabling the design of novel materials with tailored properties.
Safety and Storage
While 2'-Hydroxychalcone is not classified as highly hazardous, proper safety precautions should be observed during handling. Direct contact with skin or eyes should be avoided, and personal protective equipment, including gloves and goggles, is recommended. In case of accidental exposure, rinse thoroughly with water and seek medical advice if irritation persists. The compound should be stored in a tightly sealed container in a cool, dry place, protected from light and moisture. Prolonged exposure to air or humidity may degrade its quality. Suppliers typically provide safety data sheets (SDS) with detailed handling and storage instructions, which should be reviewed prior to use.
B2B Procurement Guide
When procuring 2'-Hydroxychalcone for B2B purposes, it is essential to verify the CAS number (492-41-1) and purity specifications, which are typically expressed as a percentage (e.g., ≥98%). Reputable suppliers should provide certificates of analysis (CoA) and safety data sheets (SDS) to ensure compliance with regulatory standards. Prices vary depending on quantity and purity, with reference ranges commonly between $50 and $200 per gram. Bulk purchases may offer cost advantages. Buyers should also consider logistical factors such as shipping conditions and lead times, especially for international orders. Establishing long-term relationships with certified suppliers can ensure consistent quality and reliable delivery.
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