Overview
2-Hydroxy-β-cyclodextrin is a chemically modified form of β-cyclodextrin, featuring a hydroxy group at the 2-position of the glucose units. This modification enhances its solubility and inclusion complex formation capabilities, making it valuable in various industries. Cyclodextrins are cyclic oligosaccharides known for their ability to encapsulate guest molecules within their hydrophobic cavities. The hydroxy group in 2-Hydroxy-β-cyclodextrin improves its interaction with polar and non-polar molecules, broadening its applications.
Physical and Chemical Properties
2-Hydroxy-β-cyclodextrin is a white or off-white powder with high water solubility, a critical property for its use in aqueous formulations. Its molecular structure consists of seven glucose units linked by α-1,4 glycosidic bonds, forming a toroidal shape. The hydroxy group at the 2-position increases its hydrophilicity compared to unmodified β-cyclodextrin. This derivative decomposes upon heating rather than melting, which is typical for cyclodextrins. Its solubility in organic solvents is limited but sufficient for certain applications.
Main Applications
In pharmaceuticals, 2-Hydroxy-β-cyclodextrin is used to enhance the solubility and stability of poorly water-soluble drugs. It forms inclusion complexes that improve bioavailability and reduce side effects. The cosmetics industry utilizes it for stabilizing fragrances and active ingredients. In food technology, it serves as a carrier for flavors and nutrients. Its role in analytical chemistry includes chiral separation and sample preparation due to its selective inclusion properties.
Safety and Storage
2-Hydroxy-β-cyclodextrin is generally recognized as safe (GRAS) for use in food and pharmaceuticals. However, dust inhalation should be avoided to prevent respiratory irritation. Proper storage in a cool, dry environment is essential to maintain its stability. Long-term exposure to moisture or high temperatures can degrade the compound. It is advisable to use sealed containers and desiccants to prolong shelf life. Always refer to the material safety data sheet (MSDS) for specific handling guidelines.
B2B Procurement Guide
When procuring 2-Hydroxy-β-cyclodextrin, prioritize suppliers who provide certificates of analysis (CoA) to verify purity and compliance with industry standards such as USP or EP. Bulk buyers should negotiate pricing based on volume and purity requirements. Consider the supplier's track record for consistency and reliability. Sampling before large-scale purchases is recommended to ensure product quality. Packaging options should align with storage capabilities to prevent contamination or degradation.
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